Research progress on the pathological mechanism of bipolar disorder with mixed features
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 10
Abstract
Bipolar disorder with mixed features is currently a prevalent clinical phenomenon, with patients exhibiting a heightened risk of suicidal behaviour, suboptimal therapeutic outcomes, poor prognostic indicators and frequently accompanied by significant impairment in psychosocial functioning. The current body of research on the pathological mechanisms of bipolar disorder with mixed features has proposed several mechanisms including neurotransmitter imbalance leading to abnormal emotion regulation, hypothalamic-pituitary-adrenal (HPA) dysfunction triggering an excessive stress response, circadian rhythm disorder affecting the sleep pattern, abnormal functional connectivity of the cerebral cortex and limbic system, independent and multidirectional changes in four dimensions, such as behaviour, cognition, mood, and sleep. Further studies are required to integrate the results of neurobiology, imaging, genetics and other multidisciplinary fields in order to provide more precise targets for the diagnosis and treatment of bipolar disorder with mixed features.
Authors and Affiliations
Ni ZHOU, Zuowei WANG, Yiming CHEN, Wu. HONG
Keywords
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- EP ID EP759182
- DOI 10.3969/j.issn.1002-0152.2024.10.009
- Views 43
- Downloads 0
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