Effect of Intravenous Administration of Tranexamic Acid in Reducing Blood Loss During and After Caesarean Section
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 7
Abstract
Objective: To determine the effectiveness and safety of intravenous tranexamic acid in reducing blood loss during and after caesarean section. Methods: A prospective randomised control study in which sixty subjects of caesarean deliveries who were included in the study were divided into two groups: Tranexamic acid (TXA) group – subjects who received tranexamic acid; and Control group - subjects who did not receive tranexamic acid. Intravenous tranexamic acid (Tranostat) 10mg/kg was administered 10 minutes prior to skin incision slowly over 5 minutes in the tranexamic acid group and 10ml of normal saline was administered in the placebo control group over 5 minutes intravenously. The amount of blood loss was measured on two occasions. The first period was from placental delivery to abdominal wound closure (in ml) and the second period from the end of LSCS to 2 hours after surgery (in ml). Results: Tranexamic acid significantly reduced bleeding from the time of placental delivery to abdominal wound closure in LSCS with blood loss of 339.0 ± 18.4 ml in tranexamic acid (TXA) group compared to blood loss of 377 ±24 ml in control group. The reduction in blood loss was statistically significant (p value= 0.000). The blood loss from abdominal wound closure to 2 hours post delivery in TXA group and control group were 48.7 ± 9.1 ml and 58.4 ± 9.7 ml respectively and the difference was statistically significant (p value= 0.001). Thus the mean total blood loss was 388.0±22.8 ml and 432.4±30.8 ml in the TXA group and the control group, respectively. The result was found to be highly significant (p value= 0.001). Conclusion: Tranexamic acid significantly reduced the amount of blood loss during and after lower segment caesarean section. It was not associated with any adverse drug reaction or thrombosis; hence it can be used safely in women undergoing LSCS
Authors and Affiliations
Khing Rushulo
Keywords
Related Articles
- EP ID EP213788
- DOI -
- Views 106
- Downloads 0
Effect of Central Corneal Thickness on Intraocular Pressure Readings by Goldmann Applanation Tonometer and Non Contact Tonometer
Purpose: To study the effect of CCT on IOP readings obtained by NCT and GAT across varying IOP ranges, and to correlate the IOP readings obtained by GAT and NCT. Methods: 230 eyes were included in this cross sectional st...
Pneumatization of the Sphenoid Sinus: A Computed Tomographic Study
Aim: The present study was done with a purpose to find out variations of sphenoid sinus and its related structure and compare these findings with other studies to note any racial differences among them. Material & Method...
Effect of Stress on Cardio Respiratory Fitness in Terms of Aerobic Power and Anaerobic Power
Back Ground And Aim: Medical students confront with significant academic, psychological, existential stress throughout their professional training therefore this study is plan to see the effect of stress on cardiorespira...
Renal Cell Carcinoma: Presentation and Management - A Single Centre Experience
Background: Renal cell carcinoma (RCC) is the one of the most lethal urological carcinoma. It has a high incidence rate in western countries as compared to the Asian countries. There is paucity of literature about the in...
Study of OSA in Chronic Obstructive Pulmonary Disease
50 patients of COPD were screened for by symptomatology, history, clinical examination, Chest X ray & spirometry. The youngest subject was 30 yrs old and the oldest 75 years. In the study, 74% were males and 26% were fem...