Effect of Intravenous Administration of Tranexamic Acid in Reducing Blood Loss During and After Caesarean Section
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 7
Abstract
Objective: To determine the effectiveness and safety of intravenous tranexamic acid in reducing blood loss during and after caesarean section. Methods: A prospective randomised control study in which sixty subjects of caesarean deliveries who were included in the study were divided into two groups: Tranexamic acid (TXA) group – subjects who received tranexamic acid; and Control group - subjects who did not receive tranexamic acid. Intravenous tranexamic acid (Tranostat) 10mg/kg was administered 10 minutes prior to skin incision slowly over 5 minutes in the tranexamic acid group and 10ml of normal saline was administered in the placebo control group over 5 minutes intravenously. The amount of blood loss was measured on two occasions. The first period was from placental delivery to abdominal wound closure (in ml) and the second period from the end of LSCS to 2 hours after surgery (in ml). Results: Tranexamic acid significantly reduced bleeding from the time of placental delivery to abdominal wound closure in LSCS with blood loss of 339.0 ± 18.4 ml in tranexamic acid (TXA) group compared to blood loss of 377 ±24 ml in control group. The reduction in blood loss was statistically significant (p value= 0.000). The blood loss from abdominal wound closure to 2 hours post delivery in TXA group and control group were 48.7 ± 9.1 ml and 58.4 ± 9.7 ml respectively and the difference was statistically significant (p value= 0.001). Thus the mean total blood loss was 388.0±22.8 ml and 432.4±30.8 ml in the TXA group and the control group, respectively. The result was found to be highly significant (p value= 0.001). Conclusion: Tranexamic acid significantly reduced the amount of blood loss during and after lower segment caesarean section. It was not associated with any adverse drug reaction or thrombosis; hence it can be used safely in women undergoing LSCS
Authors and Affiliations
Khing Rushulo
Keywords
Related Articles
- EP ID EP213788
- DOI -
- Views 102
- Downloads 0
Osteochondroma – A Rare Entity in Maxillofacial Region
Osteochondroma, also known as Osteocartilagenous exostosis is regarded as the most common benign tumour of long bones, especially in the distal metaphysis of the femur and the proximal metaphysis of the tibia. It is rela...
Computed Tomography for Staging in Head and Neck and Oral Cancer How accurate are we? Are we underestimating our clinical target volume?
Aim: To compare radiological [Computed Tomography (CT)] tumour and nodal dimensions in head and neck and oral cancer with post-operative pathological status and explore the ramifications associated with disparity. Materi...
A Comparative Study of the Efficacy of Intraumbilical Oxytocin and Intravenous Methyergometrine in the third Stage Bleeding
Aim: To compare the efficacy of intraumbilical Oxytocin and intravenous Methyl ergometrine in active management of third stage of labour. Material and Methods: This is a prospective study of 100 cases of singleton low ri...
Severe Vit B12 Deficiency Presented As Encephalopathy in a 5 Yr Child
Vit B12 plays important role in different organ in our body, most importantly haematological system and central as well as peripheral nervous system. So its deficiency in children can cause poor weight gain, developmenta...
Aggressive Digital Papillary Adenocarcinoma (ADPCA) of heel with Distant Lung Metastasis: A Rare Presentation
Aggressive digital papillary adenocarcinoma (ADPCA) is rare tumour of the sweat glands, characterised by lesions on the fingers, toes and the digits. The lesion is serious but often overlooked because it is confused clin...