Effect of intravitreal dexamethasone implant (0.7mg) on intraocular pressure when used for macular edema in real world clinical practice
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 10
Abstract
Aim: To determine the effect of intravitreal dexamethasone implant 0.7mg (Ozurdex; Allergan, Inc.) on Intra ocular pressure when used for macular edema of varying etiology. Method: Retrospective non comparative clinical case study of 49 eyes of 49 patients who received a total of 49 injections of intravitreal dexamethasone implant (0.7mg) for macular edema of varying etiology such as diabetes mellitus, vein occlusion, noninfectious uveitis and miscellaneous causes. Best corrected visual acuity, baseline intraocular pressure, status of lens, previous vitrectomy were documented. Intraocular pressure was measured using applanation tonometry on the first, third and sixth month after the injection. All patients were followed up for a period of six months. Result: A total of 49 eyes met the inclusion criteria and were analyzed. The cause for macular edema was diabetes mellitus in 22 eyes,(49.9%)) , vein occlusion in 14 ( 28.6%) uveitis 7(14.3%) and miscellaneous causes in 6 (12.2%) eyes. Mean age of patient was 57 +/- 11.4 (mean +/_ SD) with male 29(59.2%) and female 20 (40.8%). Mean (± SE) BCVA and IOP were 0.62±0.36 log MAR and 14.57±2.5 mmHg, respectively, at baseline and at last follow up at 6 months 0.54+/_0.33 log MAR and 17.29+/_2.4mmHg. Nine (4.4%) patients presented with >5mmHg of increase in IOP from baseline and responded to medical management. No anti glaucoma surgery was performed on any of these patients. There was no progression of cataract and no endophthalmitis reported. Conclusion: Nine (4.4%) patients presented with a > 5mmHg in intraocular pressure. In real life clinical practice intravitreal dexamethasone (0.7mg) is a safe option for the treatment of macular edema from various causes.
Authors and Affiliations
Elfride F. Sanjana, Sujatha Mohan, Kandaswamy Ravichandran
Keywords
Related Articles
- EP ID EP231137
- DOI 10.17511
- Views 107
- Downloads 0
Atherosclerosis regression of intima-media wall thickness of internal carotid artery with long term use of flavonoids & antioxidants
Introduction: Free radicals of oxygen causes an abnormal intravascular lipid peroxidase activity and start process of atherosclerosis within blood vessels. Atherosclerosis reversal has been studied in humans and animals....
A comparative study of Olopatadine and Ketorolac eye drop with Ketorolac eye drop alone in seasonal allergic conjunctivitis
Background: Seasonal allergic conjunctivitis is the most common allergic disorder seen in eyes. The aim of study was to compare the clinical efficacy of combination of 0.4% ketorolac and 0.1% olopatadine with 0.4% ketoro...
Psycho physical test in normal individual and diabetic patients with and without diabetic retinopathy: comparative study
Purpose: To investigate the differentiating ability of psycho physical test which include contrast sensitivity function (CSF), dark adaptation (DA) and best corrected visual acuity (BCVA) in detecting functional losses i...
Delayed anaphylaxis following propofol infusion in unknown egg allergic patient
We report a case of anaphylaxis that occurs more than one hour after propofol administration for colonoscopy. The patient did not reveal his allergy to egg in the preoperative evaluation. Administration of propofol to pa...
To evaluate and compare analgesic effects of wound infiltration with voveron with intravenous injection in cesarean section
Objectives: Postoperative pain mostly results from sensitization of afferent fibers at injury sites driving central sensitization. Recently, peripheral processes have gained attention as mechanism of hyperalgesia, and pr...