Effect of kindled seizures on rat behavior in water Morris maze test and amino acid concentrations in brain structures.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 1
Abstract
The effects of kindled seizures elicited by repeated pentetetrazole (PTZ) injections, on learning and memory in the Morris water maze test and on concentration of brain amino acids, were examined in rats. It was found that kindled seizures (a model of temporal lobe epilepsy) produced a profound decrease in learning and memory accompanied by a selective and long-lasting decrease in hippocampal and striatal concentration of glutamate, glycine and alanine in the striatum (ex vivo measurement). The concentrations of histamine, serine and gamma-aminobutyric acid (GABA) were not selectively affected by kindling. A lower concentration of glutamate and N-methyl-D-aspartate (NMDA) receptor co-agonists in the striatum (glycine and alanine) indicates the general malfunction of the brain glutamatergic system. It is suggested that a selective decrease in hippocampal glutamate concentration may account for deterioration in learning and memory processes in kindled rats, considering the important role of this neurotransmitter in the cognitive processes (e.g. in the long-term potentiation), and the key contribution of the hippocampus to the spatial memory. The intrinsic mechanisms of the reported behavioral effects may involve neuronal damage in the brain limbic structures, secondary to seizure-induced ischemia and hypoxia.
Authors and Affiliations
Janusz Szyndler, Agnieszka Piechal, Kamilla Blecharz-Klin, Anna Skórzewska, Piotr Maciejak, Jerzy Walkowiak, Danuta Turzyńska, Andrzej Bidziński, Adam Płaźnik, Ewa Widy-Tyszkiewicz
Keywords
Related Articles
- EP ID EP128750
- DOI -
- Views 137
- Downloads 0
Assessment of vascular disease using arterial flow mediated dilatation.
Arterial endothelial dysfunction occurs at all stages of atherosclerosis, both preceding structural atherosclerosis changes, as well as predisposing to clinical events in late obstructive disease. Endothelial dysfunction...
Apoptotic gene expression under influence of fludarabine and cladribine in chronic lymphocytic leukemia-microarray study.
Background: A deep insight into gene expression profiling (GEP) is a key to understanding the background of disease. It can lead to identification of diagnostic and prognostic factors and then to a selection of the most...
Anti-apoptotic effects of hyperoside via inhibition of NR2B-containing NMDA receptors.
Hyperoside (Hyp) is a flavonoid compound isolated from a folk remedy, Rhododendron ponticum L. leaves. It has been shown to have neuroprotective effects both in vivo and in vitro. However, little is known about the effec...
Metformin raises hydrogen sulfide tissue concentrations in various mouse organs.
Background: The epidemic of diabetes mellitus type 2 forces to intensive work on the disease medication. Metformin, the most widely prescribed insulin sensitizer, exerts pleiotropic actions on different tissues by not fu...
Central interaction between physostigmine and histamine during yawning in rats.
In this study, the effects of intraperitoneal (ip) injection of physostigmine, subcutaneous (sc) injection of atropine, and intracerebroventricular (icv) injections of histamine, chlorpheniramine (H(1)-receptor antagonis...