Effect of Low Dose Dexmedetomidine Infusion on Hemodynamics in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Observational Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 10
Abstract
Introduction: Dexmedetomidine is a relatively new potent and highly selective α2-adrenoceptor agonist that has been used to provide sympatholysis, analgesia and sedation in the perioperative period. We conducted this study to evaluate the effects of dexmedetomidine on the haemodynamics of patients undergoing laparoscopic cholecystectomy. Material and Methods: After obtaining approval from Hospital Ethics Committee, 60 patients undergoing laparoscopic cholecystectomy were enrolled for the study with their informed consent. They were divided into groups of thirty each. One group received propofol and dexmedetomidine during maintenance of anaesthesia while the other received only propofol. Haemodynamic parameters were noted and analysed. Results: It was found that dexmedetomidine significantly reduces heart rate, systolic, diastolic and mean arterial blood pressure values as compared to when only propofol was used, and reduces requirement of propofol while maintaining stable haemodynamics. Conclusion: Dexmedetomidine effectively attenuates haemodynamic stress response during laparoscopic cholecystectomy with reduction in requirement of concomitantly-administered propofol.
Authors and Affiliations
Sarika Ashutosh Samel, Bhaskar Murlidhar Patil, Ninad Nigalye
Keywords
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