Effect of Low-flow Sevoflurane Anaesthesia on Renal Functions in Patients Undergoing Surgery: A Retrospective Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 2
Abstract
ABSTRACT Introduction: Sevoflurane is a commonly used inhalational anaesthetic agent in India. However, there is limited information on the effect of low-flow sevoflurane anaesthesia on renal function in Indian patients undergoing major surgeries. Aim: To assess the effect of low-flow sevoflurane anaesthesia on renal parameters in adult patients undergoing elective surgery for more than two hours. Materials and Methods: This was a cross-sectional, single centre, retrospective study was conducted in the Department of Anaesthesia, Fortis Hospital, Delhi, India (November 2016 to May 2017). Change in serum creatinine and Blood Urea Nitrogen (BUN) values from baseline to postsurgery and number of patients experiencing postoperative glucosuria and proteinuria were recorded. Categorical data are presented using numbers and percentages whereas continuous data are summarised using mean and standard deviation. Statistical difference in the preoperative values of serum creatinine and BUN was evaluated using paired t-test and p-value less than 0.5 was considered statistically significant. Results: The study included 100 patients (44% males and 56% females) with mean age of 41.3±12.59 years. Mean duration of surgery was 163.3±51.78 minutes. There was no clinically significant difference in the vital parameters after surgery. Serum creatinine (0.77 vs 0.76 mg/dL; p=0.2415) and BUN (11.79 vs 12.26 mg/dL; p=0.2624) did not change significantly after surgery. None of the patients developed proteinuria or glucosuria. There was no report of change in the dose or anaesthetic drug due to intolerance or adverse event caused by sevoflurane. Conclusion: Low-flow sevoflurane can be safely administered as an anaesthetic agent in elective surgeries among Indian adult patients with normal renal functions.
Authors and Affiliations
Umesh Deshmukh
Keywords
Related Articles
- EP ID EP522284
- DOI 10.7860/JCDR/2018/34568.11200
- Views 56
- Downloads 0
Incontinence Impact Questionnaire (IIQ-7) and Urogenital Distress Inventory (UDI-6): Translation and Psychometric Validation of the Iranian Version
ABSTRACT Introduction: Urinary incontinence is a common health, physical, and social problem in the world. There is an urgent need of effective questionnaires for its evaluation in Iranian women. Aim: The present study a...
Echocardiography in Transfusion Dependent Beta Thalassaemia Major Egyptian Children: Correlation with Thyroid Function Status and Ferritin Level
ABSTRACT Introduction: Iron-mediated cardiomyopathy is leading cause of death in β-thalassaemia (βTM). Thyroid dysfunction maybe associated with cardiac dysfunctions. Early detection of cardiac-function impairment can he...
Mammary Analogue Secretory Carcinoma- A Salivary Gland Neoplasm: Case Report of an Exceptionally Rare Tumour
ABSTRACT Mammary Analogue Secretory Carcinoma (MASC) is a rare salivary gland tumour. It clinically presents as a painless mass in the parotid gland affecting mainly males. A 17-year-old male presented with 18 month hist...
Antimicrobial Resistance in Clinical Isolates of Streptococcus Pneumoniae: Mechanisms and Association with Serotype Patterns
ABSTRACT Introduction: Serotypes and antimicrobial resistance patterns of pneumococcus are dynamic and need close monitoring. The present study describes serotypes and antimicrobial resistance of pneumococcus from clinic...
A Study of Neurodevelopmental Outcome in Hyperbilirubinaemic Neonates Admitted in NICU
ABSTRACT Introduction: Hyperbilirubinaemia may be toxic to the developing central nervous system and may cause neurological impairment. The developing brain of premature babies is extremely vulnerable to injury. With inc...