Effect of Matrine Injection Combined with First-line Chemotherapy in the Treatment of Lung Cancer: a Meta-analysis
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2017, Vol 7, Issue 5
Abstract
The aim of this study is to systematically evaluate the efficacy and safety of matrine injection (MI) combined with first-line chemotherapy in the treatment of lung cancer. The search was applied to Cochrane Library, EMBASE, PubMed, Web of Science, CNKI, WANFANG DATA, VIP and CBM database from 2006 to 2016. Randomized controlled trials (RCTs) of MI combining first-line chemotherapy (versus chemotherapy alone) in any language were included. Two authors extracted data and assessed literature quality independently. Meta-analysis was conducted by using RevMan 5.3 software. Ten studies total 906 cases were included. The meta-analysis showed that compared with the first-line chemotherapy alone, the combination of MI and first-line chemotherapy in the treatment of lung cancer could not only improve the short-term clinical efficacy [RR = 1.17, 95% CI (1.02, 1.34), P = 0.02], complete response (CR) [RR = 1.46, 95% CI (0.99, 2.15), P = 0.06] and the quality of life [RR = 1.62, 95% CI (1.19, 2.20), P = 0.002], but also reduce WBC toxicity [RR = 0.39, 95% CI (0.27, 0.55), P < 0.00001] and the nausea and vomiting [RR = 0.52, 95% CI (0.37, 0.73), P = 0.0002]. Matrine injection combined with first-line chemotherapy regimen for lung cancer has a certain synergistic effect, but it needs to be further confirmed through a large sample of clinical studies
Authors and Affiliations
Yizhen Zhang, Haihua Guo, Guohua Cheng
Keywords
Related Articles
- EP ID EP433009
- DOI -
- Views 106
- Downloads 0
Reason Analysis for Suspension/Early Termination of Drug Clinical Trial
Object To collect a scientific basis for improving the quality and success rate of drug clinical trials by analyzing the reasons for the suspension or termination of clinical trials in China and abroad. Method Drug Clini...
The Ameliorative Effects of CE (A Chicken Extract) on Learning and Memory Function of Restraint-Stressed Mice
In this study, we studied the effects of Chicken Essence (CE) on learning and memory function of restraint-stressed mice. Male Kunming mice of 7-week-old were randomly divided into five groups as follows: normal control,...
The Safety of Bisphosphonates for Primary Osteoporosis: An Overview of Systematic Reviews and Meta-analysis
Introduction Bisphosphonates (BPs) are the first-line therapy for osteoporosis, especially primary osteoporosis, but many systematic reviews exist with conflicting conclusions about the safety of BPs. We performed an ove...
Study of Age, Parity and Contraceptive Use as Risk Factors in Cervical Carcinoma
Background Cervix is one of the most common genital malignancy leading to increased mortality in women, Early diagnosis by different screening modalities can reduce the mortality. Identification of high risk group and pu...
hsa-miR- 574-5p Down Regulates the Expression of CBR1 in A549 Cells and Enhances their Invasive Ability
Objective To explore the impact of CBR1expression on A549 cell proliferation and invasive ability, and investigate the regulatory function of hsa-miR-574-5p on these processes. Methods A549 cells with high and low CBR1 e...