EFFECT OF MDR1 GENE POLYMORPHISMS ON RESPONSE TO ORAL PREDNISOLONE IN EGYPTIAN IMMUNE THROMBOCYTOPENIC PATIENTS
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2018, Vol 3, Issue 4
Abstract
Immune thrombytopenia(ITP) is an autoimmune disorder characterized by heterogeneous bleeding manifestations as well as marked-inter individual variation in response to glucocorticoid (GCs); the 1st line ITP treatment. This may be due to Pgp protein; the product of ATP binding cassette B1( ABCB1) gene.IT IS involved in effluxing drugs as steroids outside the intracellular space thus decreasing its intracellular concentration. The study investigated relation between single nucleotide polymorphism (SNPs) in ABCB1gene and variation of response to oral prednisolone treatment in 100 Egyptian ITP patients. Clinical response was measured during 1st 28 days and compared with C3435T and G2677T SNPs determined by PCR REPLF technique. No signicant difference in C3435T between ITP and control. Carriers of mutant allele of G2677T were signicantly higher in ITP compared with control (p value :02) suggesting possible role in disease predisposition. But No relation was between age of onset, initial platelet count, steroid response or steroid dependence and any of both polymorphisms
Authors and Affiliations
Doaa Abd El-Reheem, Ahmed Aly, Asmaa Kasem
Keywords
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EFFECT OF MDR1 GENE POLYMORPHISMS ON RESPONSE TO ORAL PREDNISOLONE IN EGYPTIAN IMMUNE THROMBOCYTOPENIC PATIENTS
Immune thrombytopenia(ITP) is an autoimmune disorder characterized by heterogeneous bleeding manifestations as well as marked-inter individual variation in response to glucocorticoid (GCs); the 1st line ITP treatment. Th...