Effect of Methanolic Extract of Emilia Praetemissa on Paracetamol Induced Liver Damage in Albino Wistar Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
The present investigation shows the hepato-protective role of Emilia praetermissa in paracetamolinduced liver toxicity. The study was conducted using forty Albino rats randomly divided into four groups of ten rats each. Group A, the control group received tap water and animal feeds only. Group B received 2g/kg body weight of Paracetamol. Group C was administered with 500mg/kg body weight of the extract while group D received co-administration of the same concentrations of the extract and Paracetamol. All the treatment lasted for a period of 7days. Blood sample was collected from the rats through cardiac puncture under diethyl ether anaesthesia for analysis of AST, ALT, ALP, Albumin, Total protein, direct bilirubin and conjugated bilirubin. The results showed that paracetamol increased the biochemical parameters (AST, ALT) studied when compared to control while Emilia praetermissa decreased all the biochemical parameters tested. However, the extract significantly (p<0.05) reduced blood proteins such as ALB and Total proteins. Histopathological observations of liver tissues corroborated these findings. The results therefore suggest that Emilia praetermissa has protective effects on liver toxicity. Therefore, the use of E. praetermissa as vegetables and other medicinal effects could be encouraged.
Authors and Affiliations
Nzewi Juliet I. , Okojie Kenneth A, Edoga Cyril O. , Sobanke Omolara A, Nwobodo Ed2
Keywords
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- EP ID EP387023
- DOI 10.9790/3008-1106052936
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