Effect of methotrexate and doxorubicin cumulative doses on superoxide dismutase levels in childhood acute lymphoblastic leukemia
Journal Title: Paediatrica Indonesiana - Year 2015, Vol 55, Issue 5
Abstract
Background Acute lymphoblastic leukemia (ALL) is the mostcommon malignancy in children. Chemotherapeutic drugs forALL such as methotrexate (Mtx) and doxorubicin producereactive oxygen species (ROS), a type of free radical. The ROScan reduce levels of antioxidants in the body, including superoxidedismutase (SOD). Decreased SOD levels can cause DNA, lipid,and protein damage, which in turn may lead to adverse effectsand treatment failure.Objective To determine the effect of Mtx and doxorubicincumulative doses on SOD levels in children with ALL.Methods We conducted a retrospective cohort study in childrenwith ALL who underwent chemotherapy in Dr. Sardjito Hospitalin October 2011 who had completed the induction phase. Riskfactors for decreased SOD levels were analyzed by Cox regressionand hazard ratio, with a significant level of P <0.05.Results Of 40 patients enrolled, Mtx ≥ 3000 mg/m2 significantlydecreased SOD levels (HR 9.959; 95%CI 2.819 to 35.183; P=0.001). However, doxorubicin ≥90 mg/m2 did not significantlydecrease SOD levels (HR 0.59 95%CI 0.194 to 1.765; P=0.34).Conclusion Methotrexate is associated with decreased SOD levelsin children with ALL. However, doxorubicin is not associated withdecreased SOD levels in the same patient population.
Authors and Affiliations
Khalida Ningsih, Sri Mulatsih, Sasmito Nugroho
Keywords
Related Articles
- EP ID EP448558
- DOI 10.14238/pi55.5.2015.239-42
- Views 92
- Downloads 0
Associations of maternal body composition and nutritional intake with fat content of Indonesian mothers’ breast milk
Background Breast milk is the best sole food for infants in their first six months of life. Breast milk fat content accounts for the largest part of infants’ energy and may be influenced by many factors, including matern...
Diabetic ketoacidosis with acute kidney injury in prepubertal children: a report on two cases
Type 1 diabetes mellitus is a result of autoimmune damage, in which environmental factors are thought to trigger the autoimmune destruction of pancreatic ß-cells.1,2 Worldwide, an estimated 65,000 children under 15 years...
Relationship between childhood blood pressure and birth weight
cardiovascular mortality and morbidity. Some studies havereported a significant relationship between elevated blood pressurein children with low birth weight.Objective To assess blood pressure differences in primary scho...
Paternal and maternal age at pregnancy and autism spectrum disorders in offspring
Background The prevalence of autism spectrum disorders (ASDs) has increased 10 times over the past half century, while paternal and maternal age at pregnancy has also increased. Studies looking for an association between...
Depression in children with thalassemia major: prevalence and contributing factors
Background Thalassemia major is a chronic disease requiring lifetime treatment. A recent study showed that 11-62% of thalassemia patients developed depression, which is associated with high morbidity and mortality. Under...