Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study
Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2012, Vol 2, Issue 6
Abstract
Objective To determine the protective effect of morin, a flavonoid against deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats. Methods Hypertension was induced in uninephrectomized rats by weekly twice subcutaneous injection of DOCA (25 mg/kg bw) and 1% NaCl in the drinking water for six consecutive weeks. Effect of morin against DOCA-salt induced hypertension was evaluated by measuring blood pressure and performing biochemical estimations and histopathological examination of renal tissues. Results DOCA-salt hypertensive rats showed considerably increased systolic and diastolic blood pressure, serum hepatic marker enzyme activities such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT) and renal function markers (urea, uric acid and creatinine) in plasma. Oral administration of morin (25, 50 and 75 mg/kg bw) brought back all the above parameters to near normal level. Histopathology of kidney also confirmed the biochemical findings of this study. The effect at a dose of 50 mg/kg bw of morin was more pronounced than that of the other two doses (25 and 75 mg/kg bw). Conclusions These findings indicate that morin exhibits strong antihypertensive effect against DOCA-salt induced hypertension.
Authors and Affiliations
P Prahalathan, S Kumar, B Raja
Keywords
Related Articles
- EP ID EP256992
- DOI 10.1016/S2221-1691(12)60073-2
- Views 66
- Downloads 0
Establishment of an early warning system for cutaneous leishmaniasis in Fars province, Iran
Objective: To establish an early warning system for cutaneous leishmaniasis in Fars province, Iran in 2016. Methods: Time-series data were recorded from 29 201 cutaneous leishmaniasis cases in 25 cities of Fars province...
Identification and quantification of flavonoids in Carica papaya leaf and peroxynitritescavenging activity
Objective: To characterize the types, contents, and peroxynitrite-scavenging activities of flavonoids in the leaf of Carica papaya (C. papaya). Methods: Chromatographic and spectroscopic techniques along with high perfor...
Reduction of hydrogen peroxide–induced erythrocyte damage by Carica papaya leaf extract
Objective To investigate the in vitro antioxidant potential of Carica papaya (C. papaya) leaf extract and its effect on hydrogen peroxide-induced erythrocyte damage assessed by haemolysis and lipid peroxidation. Method...
Dysregulation of Notch signaling related genes in oral lichen planus
Objective: To investigate a dysregulation of Notch signaling in oral lichen planus (OLP) using public available microarray dataset. Methods: A mRNA expression profiling dataset from Gene Expression Omnibus was downloaded...
Comparison of total immunoglobulin A levels in different samples in Leghorn and broiler chickens
Objective: To standardize an ELISA protocol to quantify total immunoglobulin A (IgA) from different biological samples. Methods: Two independent experiments were conducted. In Experiment 1, total IgA levels were quantifi...