Effect of non-surgical periodontal therapy on oxidative stress markers in saliva and serum in smokers and non-smokers with chronic periodontitis
Journal Title: IP International Journal of Periodontology and Implantology - Year 2017, Vol 2, Issue 2
Abstract
Aim: The main objective of this case-control study is to determine the effect of initial periodontal treatment of scaling and root planing on oxidative stress biomarkers in smokers and non-smokers with chronic periodontitis (CP). Materials and Method: The study included 114 patients with CP (57 smokers and 57 non-smokers). Serum and saliva samples were collected and clinical periodontal measurements were recorded at baseline, first and third months after periodontal therapy. 8-hydroxydeoxyguanosine (OHdG) and enzyme activity of glutathione peroxidase (GSH-Px) were analyzed with enzyme-linked immunosorbent assay. Results: The level of 8-OHdG, and GSH-Px was found to be significantly higher in saliva and serum of both periodontitis groups. Levels of these ROS were significantly higher in smokers than in non-smokers groups. After initial periodontal treatment, levels of 8-OHdG in serum and saliva were significantly decreased in both periodontitis groups. Conclusion: Initial periodontal therapy with Scaling and Root planing will be helpful in diminishing oxidative stress in periodontitis.
Authors and Affiliations
Ramanarayana Boyapati, Srikanth C, N. Kiran Kumar, Shyam Sunder, Radhika Ramachandran
Keywords
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