Effect of Oral Zinc Sulfate on Local Inflammatory Cytokines Level in Iraqi Women Infected With Human Papillomavirus (HPV)
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 3
Abstract
This study was aimed to monitor oral zinc sulfate role on local cervical proinflammatory cytokines in HPV-infected women comparing with these cytokines before treatment application. A cervical secretion got from 28 infected women before and after treatment with zinc sulfate, these samples assessed various markers of inflammation including interleukin-1β, IL-8, and IL-12. Results manifested that improve and clear the cervical HPV infections after three months of zinc treatment 46.43% and 21.43%, respectively. Viral infections with single and multiple HPV high-risk types are raising of studied cytokines after 3-month compared with single HPV low-risk type. Moreover, this increasing was statistically significant only in IL-12 and IL-1. Women more than 30 years and with multiple HPV genotypes are the most benefit of zinc treatment had a high level of cytokines. This study concludes that IL-1 and IL-12 secretion are the most effects with zinc treatment at over three months to improve mild HPV infection with good hygiene.
Authors and Affiliations
Hula Y . Fadhil*, , Iman M. Aufi, Rana S. Aboud1, Faiza L. Tuma2
Keywords
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- EP ID EP388850
- DOI 10.9790/3008-1203011417
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