Antihyperlipidemic And Glucose Lowering Effect Of Extract Of Bioregulator Treated Okra (Abelmoschus Esculentus L.) Fruits in Triton-Induced Hyperlipidemia Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4
Abstract
Extracts from okra have been used to alleviate not only hyperglycemia but also hyperlipidemia in diabetic mice induced by alloxan and streptozocin. However, its hypolipidemic activity has not yet been clearly studied. This study was aimed to study the antihyperlipidemic potential of bioregulator treated okra fruit in triton-X induced hyperlipidemic rats. Hyperlipidemia was induced in rats by administration of triton-X (100mg/kg i.p.). After 14 days of induction, hyperlipidemic rats received AWB (okra extract treated with bioregulator, AWOB (okra extract without bioregulator) and atorvastatin up to 28 days. The extracts activities were assessed on serum blood glucose, lipid profiles, carbohydrate enzymes, antioxidant and non-enzymes antioxidant enzymes, malondialdehyde level, and HMG-CoA reductase activity of control and drug-treated rats. The extract exhibited a strong dose-dependent antihyperlipidemic activity and at dose level 400mg/kg (AWB) p.o. the extract showed a significant (P≤0.05) decrease in blood glucose, TC, TG, LDL, VLDL, MDA, gluconeogenic enzymes and significant (P≤0.05) increase in HDL-C, glycogenic enzymes, antioxidant enzymes and non-enzymes antioxidant in a dose- dependent manner comparing with standard atorvastatin- treated group. The present study demonstrated that the extract of bioregulator treated okra exhibits a potent lipid lowering activity and well compared with the atorvastatin than extract without bioregulator.
Authors and Affiliations
A. M. Esan, 1, C.O. Olaiya1 ,, V. Sameer, K. Elango2 ,, S. P. Dhanabal2
Keywords
Related Articles
- EP ID EP389960
- DOI 10.9790/3008-1204023950
- Views 79
- Downloads 0
Coenzyme Q10 Effect on Varicocele Associated Asthenozoospermia
Back Ground: Varicocele It Is One Of The Leading Causes Of Male Infertility. Although 15% Of Adult Men Are Believed To Have Either Clinical Or Subclinical Varicocele, Its Prevalence May Be As High As 40% Among Infertile...
Mini Review: Antitumor promotion as the best strategy for chemoprevention
Transformation of normal cell to cancer cell is known to be a multiple step process known as carcinogenesis. A lot of chemopreventive agents have been isolated from plant derived phytocompound reported to exhibit potent...
Effect of Extraction Solvent on the Phenolic Content, Flavonoid Content and Antioxidant Capacity Of Clove Bud
In this research, the effect of extraction solvent on the phenolic content, Flavonoid content and antioxidant capacity of clove bud (Syzygium aromaticum) was investigated. The extraction of clove bud was carried out with...
In vitro Growth Inhibition Study of Urinary Type Brushite Crystals in the Presence of Healthy Adult Urine and Tartaric acid
: Brushite or calcium hydrogen phosphate dehydrate is commonly found in urinary stones. In the present study the single diffusion gel growth technique was used to grow brushite crystals in silica hydro gel medium. It pro...
Biodiversity Studies of Insect Fauna Order Coleoptera of Ajmer
Ajmer is located in the center of Rajasthan (INDIA) between 25 0 38 “ and 26 0 58 “ north 75 0 22” east longitude covering a geographical area of about 8481sq km hemmed in all sides by Aravalli hills . About 7 miles from...