Mini Review: Antitumor promotion as the best strategy for chemoprevention
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4
Abstract
Transformation of normal cell to cancer cell is known to be a multiple step process known as carcinogenesis. A lot of chemopreventive agents have been isolated from plant derived phytocompound reported to exhibit potent anticancer activity in many cancer models in vitro and in vivo as they can inhibit the crucial process during carcinogenesis. Carcinogenesis comprises of three stages, namely initiation, promotion and progression. Due to multistep process of carcinogenesis, opportunities exist for intervention at any stages including promotion. Targeting promotion stage during carcinogenesis has become a promising approach in chemoprevention by inhibition of main events involved in this stage such as sustained cell proliferation and altered gene expression.
Authors and Affiliations
MohdRohaizadMd Roduan1
Keywords
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