Comparability in bioactivity assays of 45s5 bioglass scaffolds using simulated body fluid and rabbit blood plasma
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 4
Abstract
Currently the development of viable biomaterials for replacement of damaged or lost tissue has become a humanitarian need due to the large number of degenerative syndromes and traumas, compromising the tissue and surrounding organs. 45s5 bioactive glass has been exhaustively studied around the world forbonereplace, but it does exist several factors involved in the bioactivity which need to be analyzed, such as local protein presence or differences in carbonate disposition in the surrounding medium. Bioactive scaffolds made of bioglass 45s5 were prepared by the sol-gel via coupled to spray drying, employing polystyrene microspheres as template agents and heat treatment at 700 °C. The bioactivity was examined in vitro with simulated body fluid (SBF) and rabbit blood plasma (RBP), examined by the ability of hydroxyapatite layer to condensate on the material surface. Bioglass scaffolds and hydroxyapatite formation were characterized by Xray diffraction (XRD), surface electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). Hydroxyapatite conformation in bioscaffolds incubated in RBP determinate the dependence of CO2 disposition in order to obtain microspheres conformed by micro whisker, the typically obtained morphology in bioscaffolds incubated in SBF.
Authors and Affiliations
Abad-Javier, M. E. , Nuñez-Anita, R. E. , Cajero-Juárez, M, Contreras-García, M. E.
Keywords
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- EP ID EP395656
- DOI 10.9790/3008-1304061323
- Views 58
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