Sex hormones profiles in Iraqi males patients with symptomatic cholelithiasisbefore cholecystectomy
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 5
Abstract
Gallstone disease (GD) is a worldwide disease and it remains to be one of the most common health problems leading to surgical intervention. GB stone formation is multifactorial &many theories have been put forwardto explainthe mechanism of stoneformation. It is not fully clear if symptomatic gallstone disease is associated with a specific pattern of some hormonal abnormalities in the serum of male with symptomatic gallstone. The objective is to find the relationship between serum levels of sex hormones (free testosterone, SHBG, dihydrotestosterone (DHT),estradiol (E2), and progesterone)and gallstone formation in men.This cross-sectional study was carried on 50 males' patients and 37 healthy males as control group. After 12 hrs fasting, blood samples were collected from all subjects to evaluate the serum levels of thesex hormones (free testosterone, SHBG, dihydrotestosterone (DHT), estradiol, and progesterone).There was a significant decrease (P<0.05) in serum: free testosterone& DHT. The study also showed that there was a significant dincrease (P<0.05) in serum: SHBG& estradiol (E2) of patients with symptomatic cholelithiasis compared to healthy controls. While there was no significant change (P>0.05) in serum progesterone between patients and controls groups. Aging, over weight and obesity, physical inactivity, smoking, cardiovascular diseases, DM and renal stones were all associated with cholelithiasisin men. Conclusions:Elevation of SHBG& estradiol (E2) levels, lower free testosterone& DHT levels in the patient's serum compared to controls, which conclude that males patients with symptomatic gallstone disease was associated with some hormonal abnormality that may be the cause or the result of gallstone formation. The present study could be vital in achieving a better understanding of the pathogenesis of gallstones formation.
Authors and Affiliations
Shaymaa J. Mohammed, Mohammed A. Taher
Keywords
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- EP ID EP415690
- DOI 10.9790/3008-1305054147.
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