Evaluation of Antdiabetic, Hypocholesterolemic of Pomegranate (Punica Granatum L.) Juice Powders and Peel Powder Extracts In Male Albino Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
Punica granatum L., commonly known as pomegranate and belonging to the family of Punicacceae, is a unique plant. Two varieties of pomegranate including Manfaloty and Wonderful were used in this study. The juice powders (JP) subjected to freeze-drying and peel powder extracts (PPE) of the two varieties were used as hypoglycemic and hypocholesterolemic agents by using albino rats. The juice powder was used in two different concentrations (1 and 1.5 g/kg/day/ rat), meanwhile the peel powder extract was used in only one concentration (0.3 g/kg/day/rat). Results show the effect of JP and PPE on the glucose level of diabetic rats. The superior effect was with G6 rats administrated with 0.3 g MPE/kg/day/rat (Manfaloty peel extract) followed by G9 0.3 g WPE/kg/day/rat (Wonderful peel extract). On the other hand results show the effect of JP and PPE on the level of total cholesterol, LDL, HDL and triglycerides in rats serum as hypocholesterolemic agents. These results show that G5 (HFD+1%cholesterol+300mgMPE/kg /day/ rat) recorded the best results of all the aforementioned experiments, this could be attributed to the phenolic content in peel powder extract of pomegranate.
Authors and Affiliations
Mona Mohamed Abd E l Mageid1, Nadia Abdel Rahman Salama1 ;, Mahmoud Abd-Allah Mouhamed Saleh. , Hossam Mahmoud Abo-Taleb2
Keywords
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- EP ID EP386758
- DOI 10.9790/3008-1106025364
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