EFFECT OF ORALLY ADMINISTERED OFLOXACIN ON LEAD II ELECTROCARDIOGRAM OF DOGS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 7
Abstract
Introduction: Fluoroquinolones have been employed widely as antibiotic drugs in both human and veterinary medicine owing to their broad spectrum of antibacterial activity and excellent bioavailability. Life threatening arrhythmia has however been associated with the use of some them. This study was designed to study the possible effects of orally administered ofloxacin, a second-generation fluoroquinolone drug on the Lead-II electrocardiogram of dogs. Materials and Methods: Twelve Nigerian local dogs aged between 12 and 24 months were used in this study. Ofloxacin was orally administered at the dosage of 20mg/kg body weight daily for a period of 14 days. Lead II electrocardiographic readings were taken and measurements of the heart rate, P-wave duration, P-R interval, R-wave amplitude, QRS complex duration and QTC values were done. All clinical parameters were taken prior to administration of the drug and subsequently on days 3, 7 and 14 of treatment. Results: The major findings were a progressive increase in the heart rate from the day of the first dose to the 14th day and a significant increase in the QTc values through days 3, 7 and 14. Other parameters were however within normal range for dogs. Conclusion: This study showed that ofloxacin has a strong potential to cause QT prolongation in the dog, which could trigger the life threatening polymorphic ventricular tachycardia called Torsades de pointes in dogs. Therefore, its use in dogs should be with great caution.
Authors and Affiliations
Dr. Omobowale T.
Keywords
Related Articles
- EP ID EP630420
- DOI -
- Views 155
- Downloads 1
NEXUS BETWEEN HOT TEA CONSUMPTION AND RISK FOR ESOPHAGEAL CANCERS
Most of our lives revolve around our daily intake of caffeine which has increased dramatically over the years. However, China is known to be the largest consumer of caffeine around the world, especially in the form of te...
THE MANAGEMENT OF FISTULA-IN-ANO, USING INDUSTRIAL CABLE-TIES AS CUTTING SETONS
Introduction: Fistula-in-Ano is a common surgical pathology presenting in world wide. We used simple industrial cable-ties as setons. The main advantages of this material as it is cheap, readily available and most import...
DPP METHOD FOR THE STUDY OF MELOXICAM IN PHARMACEUTICALS
A planned method has been tested for Meloxicam estimation in dosage forms. This method based on using DPP with a DME versus Ag/AgCl as reference electrode. The best peak response was obtained at applied potential -1.2V i...
UNIT PACKAGING CONTROL OF REUSABLE MEDICAL DEVICES: EXPERIENCE OF MOHAMED V MILITARY TEACHING HOSPITAL – RABAT
Background: Patient safety has become a priority in Public Health. The quality assurance applied to hospital sterilization is based on several standards, including the Good Hospital Pharmacy Practices (GHPP). Packaging o...
ADOLESCENTS ANGER: A REVIEW
Anger is one of our most powerful emotional reaction that affects the human body. It is described as an intense feeling in response to frustration, hurt, disappointment, or threatening. Adolescents with more disorders ex...