EFFECT OF PACLITAXEL ALONG WITH DI ALLYL SULFIDE ON IMMUNO COMPETENT CELLS, IMMUNE COMPLEXES AND IMMUNOGLOBULINS CHANGES IN 7,12 DI METHYL BENZ(A) ANTHRACENE INDUCED SKIN CANCER IN WISTAR RATS
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2014, Vol 3, Issue 1
Abstract
Our recent studies have shown that naturally occurring dietary organo sulfure compounds such as di allyl sulfide and paclitaxel are capable of inhibiting polycyclic aromatic hydrocarbon (PAH) metabolism and subsequent PAHDNA adduct formation in Wistar rats. In this study these plant phenols were tested for their effects against PAHs and 7,12 Di Methyl Benz (A) Anthracene -induced skin tumorigenesis in rats. Each compounds was evaluated as a possible anticarcinogen in an initiation and promotion and a complete skin tumorigenesis protocol. In the two-stage tumor protocol in Wistar rats using 7,12-dimethylbenz(a)anthracene as the initiating agent followed by twice weekly applications of acetone as tumor promoter each plant compounds afforded significant protection against skin tumorigenicity. The protective effects were verified both by prolongation of latency period and by subsequent tumor development. Our results suggest that these plants compounds have substantial though variable potential for modifying the risk of skin tumorigenicity induced by a wide variety of chemicals and of these combinations of Paclitaxel and Di allyl sulfide was shown to have maximal chemo protective effects.
Authors and Affiliations
Muninathan N| Department of Biochemistry, Meenakshi Medical College and Research Institute, Enathur, Kanchipurm, Tamil Nadu, India, Corresponding author email: muninathanpappaiya@gmail.com, Ursula Sampson| Department of Biochemistry, Meenakshi Medical College and Research Institute, Enathur, Kanchipurm, Tamil Nadu, India, Prashanth Talikoti| Department of Biochemistry, Meenakshi Medical College and Research Institute, Enathur, Kanchipurm, Tamil Nadu, India, Uma Maheshwari| Department of Biochemistry, Meenakshi Medical College and Research Institute, Enathur, Kanchipurm, Tamil Nadu, India, Archana| Department of Biochemistry, Meenakshi Medical College and Research Institute, Enathur, Kanchipurm, Tamil Nadu, India, Kumar| Department of Biochemistry, Meenakshi Medical College and Research Institute, Enathur, Kanchipurm, Tamil Nadu, India
Keywords
Related Articles
- EP ID EP11120
- DOI -
- Views 303
- Downloads 13
PANCREATITIS SECONDARY TO ASCARIS LUMBRICOIDES: A CASE SERIES ANALYSIS
Ascaris lumbricoides infestations are endemic in tropical countries. Ascaris lumbricoides is the second most common intestinal parasite world-wide and, although the infection can be asymptomatic, in some cases it can p...
GASTRIC DUPLICATION CYST: AN UNCOMMON CAUSE OF PAIN ABDOMEN IN AN ADULT
Duplication cysts are rare congenital developmental anamolies of the gastrointestinal tract, the etiology of which is not completely understood. Multiple theories have been proposed to explain their existence including...
Compare attribution styles, job satisfaction, and death anxiety among the staff and operating personnel of Tehran Emergency Service
This study aimed to compare attributional styles, job satisfaction, and death anxiety among the staff and operating personnel of Tehran Emergency Service. This study was an Ex-Post Facto study. The statistical populatio...
EMERGING ROLE OF VITAMIN D IN HEALTH
Vit. D is a steroid prohormone. It is synthesized in the skin under ultra –violet light exposure. Traditionally, Vit.D3, cholecalciferol and calcitriol were known to have a role only in calcium and bone mineral metabo...
A Study to Evaluate the Role of Intravenous Immunoglobulin (IVIG) as an Adjuvant in the Management of Neonatal Sepsis in Preterm Babies
Introduction: Newborn children conceived before 32 weeks of incubation are genuinely immune defcient with cord blood centralization of IgG being not as much as half contrasted with those found in infants conceived at fu...