Effect of Panax ginseng on Carbamazepine Pharmacokinetics in Rabbits
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2021, Vol 18, Issue 1
Abstract
Objectives: Carbamazepine (CBZ) is a well-known drug prescribed to treat epilepsy and the preferred drug for trigeminal neuralgia. This study was conducted to investigate the effect of Panax ginseng extract (PGE) on the disposition of CBZ, a CYP3A4 substrate, in rabbits. Materials and Methods: An in vivo randomized parallel design was used to examine herb-drug interactions in 12 male rabbits distributed into 2 groups. In the 1st group (control group), 6 rabbits (control group) were administered orally with CBZ suspension (30 mg/kg/day) as a single daily dose for 10 days. In the 2nd group (test group), 6 rabbits was treated concomitantly with CBZ and a dose of PGE (2.5 mg/kg/day) at the same time as in the 1st group. Blood samples were withdrawn from the marginal ear vein of the rabbits at intervals of 0.0, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 4.0, 6.0, 12.0, and 24.0 h. Results: CBZ had no significantly different pharmacokinetic (PK) parameters, namely, Cmax, tmax, AUC0-24, AUC0-∞, t½, and Ke, when it was given alone or concurrently with PGE (p≥0.05). Conclusion: PGE may unlikely interfere with the PK of CBZ when it is co-administered with CBZ. Therefore, PGE can be used safely without precautions or dose monitoring.
Authors and Affiliations
Issam Mohammed ABUSHAMMALA, Fatma Khaled EL-SHAIKH ALI, Kamal Fakher ABU SHAMMALEH, Mohammed Mahmoud TAHA, Mohammed Yousef MIQDAD
Keywords
Related Articles
- EP ID EP693615
- DOI 10.4274/tjps.galenos.2019.24993
- Views 132
- Downloads 0
Comparative Morphological and Anatomical Studies on Morus Species (Moraceae) in Turkey
Objectives: Morus alba L., Morus nigra L., and Morus rubra L. are widely cultivated in many countries due to their nutritive, economic, and medicinal value. In this study, comparative morphological and anatomical studies...
Microemulsion Based Gel of Sulconazole Nitrate for Topical Application
Objectives: Sulconazole is a broad spectrum antifungal agent of the imidazole class used against dermatophytes and other fungi to treat skin infections. The aim of the present work was to formulate and evaluate a microem...
The Effect of Rusa unicolor Antler Deer Extracts from East Kalimantan in Bone Turnover Cell Models
Objectives: Osteoporosis is a condition characterized by skeletal degradation of osseous tissue resulting in an escalated chance of broken bones. Traditionally, Rusa unicolor horn from East Kalimantan is used to treat ma...
A Novel Genotyping Method for Detection of the Muscarinic Receptor M1 Gene rs2067477 Polymorphism and Its Genotype/Allele Frequencies in a Turkish Population
Objectives: Gene variation in the cholinergic muscarinic receptor 1 (CHRM1) has potential to become a candidate biomarker in the development of several disorders as well as drug response. In this study, a novel polymeras...
A Synbiotic Mixture Augmented the Efficacy of Doxepin, Venlafaxine, and Fluvoxamine in a Mouse Model of Depression
Objectives: Currently available antidepressant drugs have notable downsides; in addition to their side effects and slow onset of action their moderate efficacy in some individuals may influence compliance. Previous liter...