Effect of paroxetine exposure on the proteome expression of mice liver
Journal Title: International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS) - Year 2017, Vol 4, Issue 2
Abstract
Paroxetine is a Selective Serotonin Reuptake Inhibitor (SSRI) utilized for the treatment of Major Depressive and Stress issues. One of the significant drawbacks in Paroxetine treatment is the pharmaceutical impelled hepatic damage. In this study impact of paroxetine presentation on the liver were described utilizing in vivo mouse model. Swiss albino mice received the medication for distinctive time periods and the alterations in the levels of protein explored by proteomic examination. There were 44 down-controlled proteins, some of which are differentially conveyed at diverse treatment stages.
Authors and Affiliations
Sandeep Kumar Thakur, Manish Nivsarkar
Keywords
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