Effect of Phencyclidine Derivatives on Anxiety-like Behavior Using an Elevated-plus Maze Test in Mice

Journal Title: Advances in Clinical and Experimental Medicine - Year 2012, Vol 21, Issue 3

Abstract

[b]Abstract [/b] [b]Objectives. [/b]The study attempted to investigate the anti-anxiety activities of Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and some of its derivatives (M, F, L, B, S, P) with the elevated-plus maze (EPM) Test. [b]Material and Methods.[/b] Phencyclidine and its derivatives (M, F, L, B, S, P) were administrated intraperitoneally (i.p.) at a dose of 10 mg/kg to male mice. Anxiety-like behaviors were assessed using the elevated-plus maze test. [b]Results.[/b] EPM results revealed an increase in open arms time spent after applying PCP and M, L, P, and B compounds at the administered dosage. Moreover, an increase in the number of open arm entries was observed with M, P, and B compounds. The P, B and S compounds increased the locomotion of animals, too, which might be considered as the side effect to the compounds. [b]Conclusions.[/b] Considering the elevated-plus maze results, it was concluded that M and L compounds could be considered as a potential anxiolytic with less side effects due to a probable high electron donation of the methoxy group, as well as the hydrophilic properties of hydroxyl groups on these compounds.

Authors and Affiliations

Ramin Hajikhani, Abbas Ahmadi, Nima Naderi, Kayvan Yaghoobi, Zahra Shirazizand, Nazereh Rezaee, Babak Niknafs

Keywords

Related Articles

Proteomic Analysis of the Immunosuppressive Effects of Mesenchymal Stem Cells in a Rat Heart Transplantation Model

<strong>Background. </strong>Some reports suggest mesenchymal stem cells (MSCs) have immunosuppressive properties. However, conflicting evidence regarding the role of MSCs has emerged.<br /><strong>Objectives. </strong>T...

Endothelial Progenitor Cells in Diabetic Foot Syndrome

In the late 20th century endothelial progenitor cells (EPCs) were discovered and identified as cells capable of differentiating into endothelial cells. Antigens characteristic of endothelial cells and hematopoietic cells...

ESBL-Producing Escherichia coli Isolated from Children with Acute Diarrhea – Antimicrobial Susceptibility, Adherence Patterns and Phylogenetic Background

[b]Background. [/b]Escherichia coli remains the principal bacterial pathogen in childhood diarrhea and constitutes an important public health problem, especially in developing countries. Diarrheagenic E. coli strains oft...

The Potential Role of Photodynamic Therapy in the Treatment of Malignant Melanoma – an in vitro Study

[b]Background.[/b] Melanoma is the most severe of skin neoplasms as it may grow rapidly and metastasize. The application of photodynamic therapy (PDT) opens up new prospects in the treatment of this tumor. Numerous studi...

Lung Hernia &#8211; a Review

Lung hernia is a protrusion of lung tissue through one of its bounding structures. This uncommon condition develops most commonly as a result of trauma or after thoracic operations. Other lung hernias, particularly supra...

Download PDF file
  • EP ID EP97972
  • DOI -
  • Views 131
  • Downloads 0

How To Cite

Ramin Hajikhani, Abbas Ahmadi, Nima Naderi, Kayvan Yaghoobi, Zahra Shirazizand, Nazereh Rezaee, Babak Niknafs (2012). Effect of Phencyclidine Derivatives on Anxiety-like Behavior Using an Elevated-plus Maze Test in Mice. Advances in Clinical and Experimental Medicine, 21(3), 307-312. https://europub.co.uk/articles/-A-97972