Effect of Phencyclidine Derivatives on Anxiety-like Behavior Using an Elevated-plus Maze Test in Mice
Journal Title: Advances in Clinical and Experimental Medicine - Year 2012, Vol 21, Issue 3
Abstract
[b]Abstract [/b] [b]Objectives. [/b]The study attempted to investigate the anti-anxiety activities of Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and some of its derivatives (M, F, L, B, S, P) with the elevated-plus maze (EPM) Test. [b]Material and Methods.[/b] Phencyclidine and its derivatives (M, F, L, B, S, P) were administrated intraperitoneally (i.p.) at a dose of 10 mg/kg to male mice. Anxiety-like behaviors were assessed using the elevated-plus maze test. [b]Results.[/b] EPM results revealed an increase in open arms time spent after applying PCP and M, L, P, and B compounds at the administered dosage. Moreover, an increase in the number of open arm entries was observed with M, P, and B compounds. The P, B and S compounds increased the locomotion of animals, too, which might be considered as the side effect to the compounds. [b]Conclusions.[/b] Considering the elevated-plus maze results, it was concluded that M and L compounds could be considered as a potential anxiolytic with less side effects due to a probable high electron donation of the methoxy group, as well as the hydrophilic properties of hydroxyl groups on these compounds.
Authors and Affiliations
Ramin Hajikhani, Abbas Ahmadi, Nima Naderi, Kayvan Yaghoobi, Zahra Shirazizand, Nazereh Rezaee, Babak Niknafs
Szczepy Escherichia coli wytwarzające β-laktamazy ESBL izolowane od dzieci z ciężką biegunką – wrażliwość na leki, typy adhezji i pochodzenie filogenetyczne
[b]Wprowadzenie.[/b] Escherichia coli pozostaje nadal głównym bakteryjnym patogenem biegunek u dzieci, stanowiąc istotny problem zdrowotny, zwłaszcza w krajach rozwijających się. Szczepy E. coli wywołujące biegunki częst...
Clinical Picture of Classical, Atypical and Silent Celiac Disease in Children and Adolescents
<strong>Background. </strong>Celiac disease is a frequent disease of the alimentary tract in children. Clinical presentation of the disease is variable and depends on type of the disease.<br /><strong>Objectives. </stron...
Second-Trimester IL-15 and IL-18 Levels in the Amniotic Fluid of Fetuses with Normal Karyotypes and with Chromosome Abnormalities
[b]Background.[/b] Little is known about the behavior of interleukin 15 (IL-15) and 18 (IL-18) in the amniotic fluid in the second trimester of gestations complicated by chromosomal defects in the fetus. Likewise, it has...
Pelvi-caliceal Collecting System in Swine – Authors Own Anatomical Classification
[b]Background[/b]. Experiments on humans and their organs produce legal, moral and ethical dilemmas. Nowadays, the use of domestic swine as an experimental animal is increasing steadily. Thus it is important to know the...
Urinary Incontinence in Women and Its Relation with Pregnancy, Mode of Delivery, Connective Tissue Disease and Other Factors
[b]Objectives.[/b] The aim of this study was to determine the relationship between urinary incontinence (UI) and parameters such as pregnancy, mode of delivery and other factors. [b]Material and Methods.[/b] The study w...