Effect of phosphocreatine on ocular hemodynamics and functional status of the macula in patients with dry age-related macular degeneration

Journal Title: Офтальмологический журнал - Year 2017, Vol 0, Issue 3

Abstract

Background. Age-related macular degeneration (AMD) comprises 12.5% and 22% in the structure of ocular incapacitation among persons of working and pension age, respectively. The important role in the pathogenesis of AMD belongs to ocular hemodynamics disorders. The lack of efficacy of a therapy for AMD determines the need to search for new drugs which would improve ocular hemodynamics in the disease. Purpose. To study the effect of phosphocreatine on ocular hemodynamics and the functional state of the macular area in patients with dry age-related macular degeneration. Material and Methods. Twenty-three patients (36 eyes) comprised Study group in which a complex therapy included phosphocreatine as a Neoton drug, in a dose of 1 g diluted in 50 ml of 0.9% sodium chloride, for 8 days. Twenty-five patients (39 eyes), comprising Control group, did not receive phosphocreatine in their treatment. Each patient was performed ultrasonic Doppler examination of the ophthalmic artery and a photostress test. Results. After treatment, the values of Doppler examination and photostress test were improved only in patients of Study group. Maximal and minimal blood flow velocity in the ophthalmic artery increased by 29% and 30%, respectively; vascular resistance index decreased by 14%; and photostress recovery time decreased by 33%. These indices did not change significantly in Control group patients. Conclusions. Inclusion of the phosphocreatine-containing drug in the complex therapy for the patients with dry AMD corrects ocular hemodynamics disorders, improves the functional state of the macular area and improves treatment outcomes.

Authors and Affiliations

V. Savko Snr

Keywords

Related Articles

Our current understanding of metastasis and the potential for predicting the course of head and neck squamous cell carcinoma

This review presents recent studies on the mechanisms of malignant neoplasm metastases, particularly, in head and neck squamous cell carcinoma (HNSCC). The involvement of circulating tumor cells (CTC) and cancer stem cel...

Prediction of inpatient treatment duration for cataract patients according to their clinical and social status

The purpose of the paper was to ground and to develop a model for predicting the duration of inpatient treatment of a cataract patient. We surveyed 60 cataract patients applied for surgical treatment in Hirchman Kharkiv...

Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus

Background: Compared to patients without diabetic retinopathy (DR), those with DR demonstrate better cognitive performance. It is therefore reasonable to hypothesize that retinal microcirculatory changes might be a marke...

Relationships of vascular endothelial growth factor (VEGFA) with stage of diabetic retinopathy and disease duration in patients with type 2 diabetes mellitus

Background: As there is currently an epidemic of type 2 diabetes mellitus (T2DM), increasing attention should be paid to diabetic retinopathy (DR), a major complication of the disease which can lead to disability and bli...

Structure of the chorioretinal complex in the rabbit eye after vitrectomy. Report 2. Vitreous cavity irrigation with different temperature solutions for 60 minutes

Background: It remains poorly understood what should be the temperature of the irrigation solution for intraocular surgery and how long it is reasonable to use irrigation solutions during vitrectomy. Purpose: To investi...

Download PDF file
  • EP ID EP249169
  • DOI -
  • Views 112
  • Downloads 0

How To Cite

V. Savko Snr (2017). Effect of phosphocreatine on ocular hemodynamics and functional status of the macula in patients with dry age-related macular degeneration. Офтальмологический журнал, 0(3), 15-19. https://europub.co.uk/articles/-A-249169