Effect of pregnancy and tobacco smoke on the antioxidant activity of rutin in an animal model.
Journal Title: Pharmacological Reports - Year 2009, Vol 61, Issue 5
Abstract
Tobacco smoke is a source of free radicals and causes oxidative stress in smokers' tissues. The aim of the current study was to evaluate the effect of rutin on the total antioxidant status (TAS) in pregnant and non-pregnant rats that were exposed to cigarette smoke. TAS in brain, lungs, liver, kidneys and plasma were measured by the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical-cation decolorization assay. In pregnant rats, a diversified distribution of endogenous antioxidants was found in comparison to the matched non-pregnant animals. In pregnant rats, TAS was higher in plasma (by 33%) and kidney (by 76%), and lower in brain (by 48%) and liver (by 50%) compared with non-pregnant rats. Generally (except liver), exposure to tobacco smoke caused an increase in the antioxidative status of pregnant compared to non-pregnant animals (by 29, 16, 18 and 87% in plasma, brain, lung and kidney, respectively). Overall, rutin had little (plasma, non-pregnant rats) or a no protective effect in the examined tissues.
Authors and Affiliations
Ewa Florek, Wojciech Piekoszewski
Keywords
Related Articles
- EP ID EP96909
- DOI -
- Views 104
- Downloads 0
CCN2 protein is an announcing marker for cardiac remodeling following STZ-induced moderate hyperglycemia in mice.
Diabetes causes changes in the myocardium, which are often called diabetic cardiomyopathy. This condition has been extensively investigated in animal models with high glucose levels. Nevertheless, it has not been investi...
Effects of new antiepileptic drugs and progabide on the mitogen-induced proliferative activity of mouse splenocytes.
Classical antiepileptic drugs are known to affect immune system activity, although the effects of new generation anticonvulsants on T- and B-cell-mediated immunity remain unknown. Therefore, in the present study, we comp...
Elimination kinetics of the novel prodrug cinazepam possessing psychotropic activity in mice.
The kinetics of excretion of the novel tranquilizer cinazepam (3-hydroxy-7-bromo-5-(ortho-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one hemisuccinate (I)) in mice after a single administration and different schemes...
Mechanisms and pharmacology of diabetic neuropathy - experimental and clinical studies.
Neuropathic pain is the most common chronic complication of diabetes mellitus. The mechanisms involved in the development of diabetic neuropathy include changes in the blood vessels that supply the peripheral nerves; met...
Asymmetric dimethylarginine (ADMA) a novel cardiovascular risk factor - evidence from epidemiological and prospective clinical trials.
There is a growing clinical evidence to support the hypothesis that asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase is a new independent cardiovascular risk factor. ADMA mediates endo...