Effect of premedication with oral pregabalin in patients posted for lower limb orthopedic surgeries under spinal anesthesia: A prospective, double-blind, randomized study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 12
Abstract
Background: Pregabalin which is a GABA analogue when administered orally in preoperative period has been reported to prolong the blockade of spinal anaesthesia and reduce acute postoperative pain. So we designed the study to evaluate the efficacy of a single dose of oral pregabalin in terms of duration of spinal blockade and need for rescue analgesia. Materials and Methods: A prospective, randomised, double blind study was carried out on 50 patients with ASA physical status I & II aged between 18–50 years. Both the groups received tablets 1 hour prior to spinal anaesthesia. Group C (control group)- received colour matched placebo, while Group P (pregabalin group)– received 150mg of oral pregabalin. Spinal anaesthesia was administered to the patients in sitting position in L3-L4 space with Inj. Bupivacaine heavy (0.5%) at a dose of 0.3mg/kg body weight using 25 gauge spinal needle. Rescue analgesia was provided with using Inj. Diclofenac 1.5 mg/kg intramuscular. Results: The duration of sensory and motor blockade was significantly prolonged in group P patients when compared with that in group C patients, and the VAS scores at postoperative 6 and 24 hours were significantly lower in group P patients. Requests for analgesics during the first postoperative 24 hours were lower among group P patients. Conclusion: Premedication with a single dose of 150mg oral pregabalin 1 hr before surgery promoted the efficacy of spinal anaesthesia and improved postoperative analgesia in patients undergoing for lower limb orthopedic surgery under spinal anesthesia.
Authors and Affiliations
Vijay Patil
Keywords
Related Articles
- EP ID EP521226
- DOI -
- Views 50
- Downloads 0
Study of Surgically Induced Astigmatism after phacoemuldification at Northern Railway Central Hospital
Introduction: Surgically induced astigmatism is the difference between preoperative and postoperative astigmatism. Aims: To study surgically induced astigmatism after phacoemulsification cataract surgery performed for ag...
Vitamin D: A Review on Functions and Requirements (Part II)
Vitamin D a fat soluble vitamin is also a hormone which along with its effect on bone mineralization, exerts its effect on cells by binding to Vitamin D receptor present on most cell types in the body. Its broad spectrum...
One Year Prospective Study on Uterine Cervix: CIN-III Associated with Microinvasive Squamous Cell Carcinoma of Cervix
Background: Microinvasive squamous cell carcinoma of the uterine cervix is purely diagnosed by microscopic findings only. It has been poorly defined in the past and till today it is a focus of persistent controversy. Aim...
MRI in Clinically Suspected Uterine and Adnexal Lesions- the Conflict Resolved
Background: The purpose of this study was to evaluate the role of Magnetic Resonance imaging (MRI) in evaluation of clinically suspected uterine and adnexal lesions. Aim of Study: To evaluate the role of Magnetic Resonan...
Rheumatological Manifestations in Diabetic Population in a Tertiary Care Hospital
Rheumatological disorders in the patient of diabetes are very common still these are neglected. This was an observational, prospective hospital based study conducted on 200 diabetic patients from IGIMS OPD, Department of...