Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice
Journal Title: مجله علمي دانشگاه علوم پزشكي كردستان - Year 2018, Vol 23, Issue 95
Abstract
Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice. Materials and Methods: Twenty female pregnant mice were randomly divided into stress and control groups. The stress group received stress using a restraint cylinder (6 cm ID, 20 cm L) 60 min/day from the 1st to the 15th day of pregnancy. The control group did not receive stress. The male F1 offspring was nursed by their mothers (n=10/group) until reaching weights between 20 and 25 g. Then they were tested for spatial memory using Barnes maze and anxiety-like behavior by the elevated plus-maze. Also, brain BDNF level was measured by means of an ELISA reader. Results: Barnes maze test results showed that the time and distance to reach the target hole were significantly (p<0.001) increased in the stress group. Also, the number of errors and anxiety-like behavior in the stress group were significantly (p<0.001) increased compared to those in the control group (p<0.001). BDNF level in the brain was significantly (p<0.05) higher in the control group. Conclusion: The present study indicated that prenatal stress can lead to decreased level of BDNF in the brain of the offspring which may result in spatial memory disorder and anxiety-like behavior.
Authors and Affiliations
MSc N Aliabadi, PhD H Hedayat Sahraei, PhD Z Bahari, PhD G. H Meftahi
Keywords
Related Articles
- EP ID EP364307
- DOI -
- Views 61
- Downloads 0
The effect of eight weeks of aerobic training on serotonin and tryptophan hydroxylase levels in hippocampus in type 2 diabetic rats
Backgrounds and Aim: Aerobic exercise has proven benefits in treating and reducing the incidence of complications of chronic diseases such as diabetes. In this study we evaluated the effect of aerobic training on seroton...
Comparison the effects of ginger (Zingiber officinale) jelly and piroxicam jelly on pain of knee osteoarthritis
Background and Aim: Oral drugs and nonsteroidal anti-inflammatory drugs which are used to relieve pain are associated with certain side effects in the patients with knee osteoarthritis. The aim of this study was to compa...
Assessment of urban air quality in Sanandaj city and attribution of cardiovascular- respiratory diseases, and preterm birth in 2015-16
Background and Aim: Over the past decades, air pollution in the urban areas has shown an increasing trend. Air pollutants have resulted in different diseases. The aim of this study was to study the air quality in Sananda...
The prevalence of van gene alleles in clinical isolates of Staphylococcus aureus
Background and Aim: Staphylococcus aureus can cause a range of diseases including skin disorders, food poisoning and nosocomial infections. Resistance to antibiotics is a major problem and widespread use of antibiotics p...
Effect of vitamin C on colony formation of ovine spermatogonial stem cells in vitro
Background and Aim: The technology of using spermatogonial stem cells (SSCs) has been limited due to lack of an ideal culture system for growth and proliferation. The aim of this study was to investigate the effects of d...