Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice
Journal Title: مجله علمي دانشگاه علوم پزشكي كردستان - Year 2018, Vol 23, Issue 95
Abstract
Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice. Materials and Methods: Twenty female pregnant mice were randomly divided into stress and control groups. The stress group received stress using a restraint cylinder (6 cm ID, 20 cm L) 60 min/day from the 1st to the 15th day of pregnancy. The control group did not receive stress. The male F1 offspring was nursed by their mothers (n=10/group) until reaching weights between 20 and 25 g. Then they were tested for spatial memory using Barnes maze and anxiety-like behavior by the elevated plus-maze. Also, brain BDNF level was measured by means of an ELISA reader. Results: Barnes maze test results showed that the time and distance to reach the target hole were significantly (p<0.001) increased in the stress group. Also, the number of errors and anxiety-like behavior in the stress group were significantly (p<0.001) increased compared to those in the control group (p<0.001). BDNF level in the brain was significantly (p<0.05) higher in the control group. Conclusion: The present study indicated that prenatal stress can lead to decreased level of BDNF in the brain of the offspring which may result in spatial memory disorder and anxiety-like behavior.
Authors and Affiliations
MSc N Aliabadi, PhD H Hedayat Sahraei, PhD Z Bahari, PhD G. H Meftahi
Keywords
Related Articles
- EP ID EP364307
- DOI -
- Views 70
- Downloads 0
Evaluation of the survival rate and its related factors in patients with leukemia in Kurdistan Province
Background and Aim: In recent decades, the survival rates of the children with cancer have improved significantly and their five-year survival rates have reached 80%, but there are still many concerns about the survival...
Analysis of the factors affecting survival of the kidney transplant patients by means of penalized splines model
Background and Aim: Various methods are used to analyze the data in survival studies. The aim of this study was to compare the analysis results of penalized splines in Cox model and Cox proportional hazards model in rela...
The effect of twelve weeks of aerobic training on serum levels of interleukin-6, vaspin and serum amyloid A in postmenopausal women with metabolic syndrome
Background and Aim: Increase in some inflammatory factors secreted by the adipose tissue can have predisposing effect on the development of metabolic syndrome. This study aimed to assess the effect of 12 weeks of aerobic...
Efficacy of photocatalytic removal of Chromium in the presence of organic matter from aqueous medium by useing TiO2 nanoparticles synthesized by sol gel
Background and Aim: Widespread use of Chromium and their compounds in many industries, including plating, steel production, and wood protection and tanning leather, can result in the discharge of large amounts of polluta...
Analgesic effect of Jasminum sambac hydro alcoholic extract in rats: role of the GABAergic and opioidergic pathways
Background and Aim: There are several reports about analgesic, anti-depressant, anti-inflammatory, antiseptic, sedative, and anti-spasmodic effects of Jasminum sambac. The aim of this study was to investigate the analges...