Effect of Pro197Leu Polymorphism of the Gene GPX1 on Carbohydrate Metabolism and Anthropometric Indices of Patients with Arterial Hypertension Against the Background of Abdominal Obesity
Journal Title: Міжнародний ендокринологічний журнал - Year 2013, Vol 6, Issue 54
Abstract
The aim of our study was to investigate the dependence of carbohydrate metabolism in patients with arterial hypertension and concomitant abdominal obesity depending on Pro197Leu polymorphism of the GPX1 gene. Pro197Leu polymorphism of the gene GPX1 in 102 patients with arterial hypertension and concomitant abdominal obesity and 97 healthy individuals have been studied. Disorders of distribution of genotype frequencies comparing with the control group on account of the reduction of Pro/Pro genotype frequency have been found in the main group. Analyzing the data, the growth of risk of disorder in the GPX1 activity in patients with Pro/Leu and Leu/Leu variants of polymorphism comparing with homozygotes for the wild allele at 4.7 and 6.9 times, respectively had been revealed. Analyzing changes of carbohydrate metabolism depending on the Pro197Leu polymorphism of the gene GPX1, it was established that in patients with Leu/Leu genotype the production of immunoreactive insulin, leptin, C-peptide increased significantly, HOMA-IR and BMI was significantly higher compared with the persons with Pro/Pro genotype. Thus, Pro-allele possesses protective properties as to the reduction in the activity of glutathione peroxidase. Insulin and leptin resistance develop in the carriers of Leu-allele, which causes disturbances in carbohydrate metabolism.
Authors and Affiliations
N. O. Abramova, N. V. Pashkovska
Keywords
Related Articles
- EP ID EP233149
- DOI -
- Views 78
- Downloads 0
Laboratory Diagnosis and Management of Gestational Diabetes at the Present Stage
The need for timely and accurate diagnosis of gestational diabetes is determined by a high incidence of pregnancy complications and neonatal morbidity in this pathology. Glycated hemoglobin, which gives an integrated vie...
Features of Clinical Picture, Course and Treatment of Patients with Gout on the Background of Hypothyroidism
Aim was to study the prevalence of subclinical and manifest hypothyroidism in patients with gout, its impact on the clinical presentation and course of the disease, correction of treatment by inclusion in a treatment pro...
State of Left Ventricular Systolic and Diastolic Function in Patients with Postinfarction Cardiosclerosis and Obesity
Cardiovascular diseases are one of the major causes of mortality worldwide, the main contribution to its structure belongs to ischemic heart disease. One of the major factors for the progression of ischemic heart disease...
Violations of the System of Lipid Peroxidation in Type 2 Diabetes Mellitus (Literature Review)
The review presents the data on the current state of the problem of diabetes mellitus type 2 and the role of oxidative stress. Over the last decade, the number of patients with diabetes mellitus has increased by more tha...
Subclinical Hypercorticism: the Necessity of Diagnostic Search
Considering certain difficulties in subclinical hypercorticism diagnosis, the object of this work is to focus attention of doctors in different areas on the necessity of thorough examination of patients with pathological...