Effect of Pyridostigmine on Ovulation Rate in ClomipheneResistant PCOS Women
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Background: Polycystic ovary syndrome is the commonest endocrine disorder in women of reproductive age. It affects round 4-9% of women in reproductive age. Aim of the Work: to investigate the effect of pyridostigmine on the ovulation rate in clomiphene resistance PCOS women. Patients and Methods: This clinical trial was conducted on 246 women with clomiphene resistant polycystic ovarian syndrome at Ain-Shams University Maternity Hospital on the period from November 2014 till August 2018. Each woman received clomiphene citrate 100 mg orally from day 3 until day 7. In addition to the clomiphene citrate, each patient received pyridostigmine, 60mg twice daily orally, from day 3 of menstrual cycle till the day of hCG injection. Results: pyridostigmine cotreatment during the follicular phase resulted in improvement of ovulation rate (51.2%) and pregnancy rate (15.4%). Although we did not have any control groups receiving placebo or CC alone, each patient can serve as her own historical control by her previous resistance to 150 mg of CC. Conclusion: Addition of pyridostigmine to CC is an effective, inexpensive and safe method for stimulating follicular development in CC-resistant PCOS and may be contemplated before gonadotrophins and laparoscopic ovarian drilling.
Authors and Affiliations
Mohammad H. Nasr Al-Din, Hesham M. Harb, Mohammad H. Mostafa
Keywords
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- EP ID EP574548
- DOI 10.9790/0853-1804136167.
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