Effect of Ruta graveolens on pentylenetetrazol and electrically induced convulsions in albino mice
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 3
Abstract
Ruta graveolens is a plant commonly found in north Africa and south Europe. It is reported that Ruta graveolens is used traditionally for children epilepsy. The chemically induced convulsion by pentylenetetrazol (PTZ) is commonly used for the investigation of anti-epileptic effects of drugs. Ruta graveolens alcoholic extract residue (whole plant) was tested against PTZ and electrically induced convulsions in albino mice. The supramaximal electroshock (MES) method was applied in this study as electrically induced convulsion model; it is a simple model of generalized or partial seizures. Two concentrations of alcoholic extract were used (5 and 10%) orally. The treated animals showed significant inhibition of straub tail reaction, myoclonic jerks, clonic convulsions, final tonic extensor spasm and a significant protection against death (100% protection at 10% w/v concentration). The results indicated that Ruta graveolens contains compound(s) capable to inhibit convulsions
Authors and Affiliations
Shaban E. A. Saad
Keywords
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- EP ID EP411335
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