EFFECT OF TAMSULOSIN A SELECTIVE α1-ANTAGONIST ON GLUCOSE HOMEOSTASIS IN RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 3
Abstract
Objective: To assess the effect of tamsulosin (α1-antagonist) on blood sugar and adrenaline levels in rats.Methods: Wistar rats were divided in to four groups (n=6), Group-I (Normal control) administered normal saline, Group-II, Group-III &Group-IV induced diabetes by administering Streptozotocin IV 50 mg/kg. Group III and Group-IV were administered Tamsulosin 1mg/kg and Glimepiride 10µg/kg respectively for twenty one days. Serum insulin, adrenaline and blood glucose were estimated at before and after drug treatment.Results: Adrenaline and insulin levels were increased significantly (p<0.005) in Diabetic control and Tamsulosin treated diabetic rats compared to Normal control rats. Blood glucose levelsincreased significantly (p<0.005) in Tamsulosin treated diabetic rats compared to Diabetic control rats. All the three parameters are compared at the end of drug treatment.Conclusion: Several studies interpreted a potential role of the α-receptor in glucose metabolism. Inhibition of the α1-receptor pathway can lead to a decreased glucose uptake, and hence an increased plasma glucose concentration. Several studies in one or the other way indicating the correlation between diabetes and BPH and probably in such condition tamsulosin a α1 antagonist is the drug of choice along with oral hypoglycemic agents. Literature survey also shows that there is increase in the blood glucose levels during the use of tamsulosin which impacts blood sugar levels especially in diabetic state. T.h.is study shows increase in blood glucose levels with the use of tamsulosin is making further complications in diabetic patients. This adverse drug reaction and the proposed mechanism need to be proven further.Â
Authors and Affiliations
Gurudatta Moharir, Shivaprasad K, Ambadasu Bharatha, A A Naikawadi, Wali R. S.
Keywords
Related Articles
- EP ID EP578965
- DOI -
- Views 74
- Downloads 0
A STUDY COMPARING THE ANORECTIC ACTIVITY OF HOT AND COLD AQUEOUS EXTRACTS OF DOLICHOS BIFLORUS LINN. SEEDS IN FREELY FEEDING RATS
Objective: The aim of the study was to evaluate the anorectic activity of hot (pre-cooked under pressure) and cold (soaked overnight) aqueous extracts of the seeds of D. biflorus in freely feeding Wistar albino rat model...
LINEAR ASSESSMENT OF CEREBRAL AUTOREGULATION IN IDIOPATHIC PARKINSON'S DISEASE
Parkinson’s disease cases have been on the rise in the recent years, which promoted several different researches into the disorder. However, there hasn’t much research been done in the non-motor aspects of the diseas...
FORMULATION AND EVALUATION OF HERBAL LIPSTICKS FROM CARROT (DAUCUS CAROTA L) EXTRACT
Objective: To prepare and evaluate natural lipsticks made from the standardized extract of carotenoid of carrots (Daucus carota L) with a variety of castor oil base and an irritation test.Methods: The shade-dried coarsel...
IN VITRO STUDY ON RELEASE OF BIOACTIVE ANTIMICROBIAL COMPOUNDS FROM DAIRY PRODUCTS BY CERTAIN PROMISING PROBIOTIC LACTOBACILLUS STRAINS
Objective: The antimicrobial activity and Probiotic properties of Lactobacillus species were evaluated. The antimicrobial compound of potent antimicrobial probiotic Lactobacillus was purified by column chromatography and...
FAMILY ACANTHACEAE AND GENUS APHELANDRA: ETHNOPHARMACOLOGICAL AND PHYTOCHEMICAL REVIEW
Aphelandra belong to family Acanthaceae. We have reviewed traditional uses, pharmacological potential and phytochemical study of family Acanthaceae and genus Aphelandra. Traditionally the most important part use in Acant...