Effect of Taurine Pre-treatment on Hematological Parameters in Isoproterenol Induced Myocardial Infarction in Albino Rats
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 3
Abstract
Cardiovascular diseases form the major health concern in recent years, causing severe illness and death throughout the world. About 16.7 million people around the globe die of myocardial infarction every year (WHO 2004) which forms one third of global deaths. Clinically, taurine has been widely used in variety of conditions including cardiovasculardiseases, hypercholesterolemia, macular degeneration, Alzheimer’s disease, hepatic disorders, alcoholism and in cystic fibrosis. The present study was designed to investigate the effect of taurine pre treatment on hematological parameters in isoproterenol induced myocardial infarction in albino rats by demonstrating the hematological changes. Wistar male rats were randomly divided into four groups namely Control (G1), taurine (G2), isoproterenol (G3) and Isoproterenol + taurine (G4). Taurine treated group-received taurine (100mg/kg body wt) orally for 30 days. Myocardial infarction was induced in rats by isoproterenol administration (100mg/kg) subcutaneously (sc) at an interval of 24 hrs on 31st and 32nd day. Hematological changes were assessed from 24 hrs after the last dose of isoproterenol. There was decrease in RBC count, WBC count, Platelet count, Hb%, Lymphocyte count, Eosinophil count and increase in Neutrophil count in G4 rats as compared to G3 rats. Taurine pretreatment preserved the changes to near normal. Taurine may provide cardioprotection under conditions of ischemia-reperfusion due to its antioxidant properties. It may prevent oxidant-mediated damage of the cardiomyocyte membrane and subsequent intracellular Ca2+ overload. Keywords: Taurine, Hematological changes, Myocardial infarction, Wistar strain male albino rats
Authors and Affiliations
M. Sudha, D. Rajkumar
Keywords
Related Articles
- EP ID EP373705
- DOI -
- Views 58
- Downloads 0
Gender variations in cardiovascular responses to Cold Pressor Test in Normal subjects
Abstract: Abnormal Cold Pressor Response [CPT] is one of the important characteristic of autonomic dysfunction as well as future development of hypertension. Appropriate identification and intervention at early stages ca...
Clinico-pathological profile of tuberculosis of the head and neck region from a tertiary care teaching hospital
Tuberculosis of the head and neck region may often mimic malignancy and misdiagnosed which leads to an unnecessary delay in diagnosis. Better understanding of this topic would help us to make early diagnosis thus timely...
Hematological profile of normal pregnant women in Western India
Anemia is a common problem during pregnancy and no reference values have been reported for hematological parameters during pregnancy in rural population. Present study was aimed to study the hematological variations duri...
Hypovitaminosis D and Pulmonary Tuberculosis: A Study in a Tertiary Care Institute of Mewat
Abstract: Tuberculosis (TB) remains a major challenge to global public health. Vitamin D is an immunoregulatory hormone. Epidemiological evidence also suggests a link between vitamin D deficiency, serum calcium, serum ph...
Study of Cardiac Autonomic Neuropathy and Its Association with Qtc Dispersion in Type-2 Diabetes Mellitus Patients Attending Rural Medical College
Abstract: The prevalence of diabetes is on the rise, ranked seventh among leading cause of death. One of the major reasons for death among diabetes patient is cardiac autonomic neuropathy. Studies have found that QTc dis...