Effect of Taurine Pre-treatment on Hematological Parameters in Isoproterenol Induced Myocardial Infarction in Albino Rats
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 3
Abstract
Cardiovascular diseases form the major health concern in recent years, causing severe illness and death throughout the world. About 16.7 million people around the globe die of myocardial infarction every year (WHO 2004) which forms one third of global deaths. Clinically, taurine has been widely used in variety of conditions including cardiovasculardiseases, hypercholesterolemia, macular degeneration, Alzheimer’s disease, hepatic disorders, alcoholism and in cystic fibrosis. The present study was designed to investigate the effect of taurine pre treatment on hematological parameters in isoproterenol induced myocardial infarction in albino rats by demonstrating the hematological changes. Wistar male rats were randomly divided into four groups namely Control (G1), taurine (G2), isoproterenol (G3) and Isoproterenol + taurine (G4). Taurine treated group-received taurine (100mg/kg body wt) orally for 30 days. Myocardial infarction was induced in rats by isoproterenol administration (100mg/kg) subcutaneously (sc) at an interval of 24 hrs on 31st and 32nd day. Hematological changes were assessed from 24 hrs after the last dose of isoproterenol. There was decrease in RBC count, WBC count, Platelet count, Hb%, Lymphocyte count, Eosinophil count and increase in Neutrophil count in G4 rats as compared to G3 rats. Taurine pretreatment preserved the changes to near normal. Taurine may provide cardioprotection under conditions of ischemia-reperfusion due to its antioxidant properties. It may prevent oxidant-mediated damage of the cardiomyocyte membrane and subsequent intracellular Ca2+ overload. Keywords: Taurine, Hematological changes, Myocardial infarction, Wistar strain male albino rats
Authors and Affiliations
M. Sudha, D. Rajkumar
Keywords
Related Articles
- EP ID EP373705
- DOI -
- Views 48
- Downloads 0
Scrub Typhus – A re-emerging illness in a tertiary care center in southern Odisha
Abstract:Scrub typhus is an acute febrile illness and now one of the important causes of fever of unknown origin (FUO) in paediatric age group. It generally presented with fever along with nonspecific symptoms without an...
Prevalence of Generalized Anxiety Disorder in Chronic Obstructive Pulmonary Disease Patients and General Population
Abstract: Emerging evidence suggests significant influence of comorbid anxiety on COPD. Several studies have reported a high prevalence of anxiety in COPD, but the rates vary widely. Review articles have reported the pre...
Apache II Score and Perforation Peritonitis
Abstract: Peritonitis is a demanding surgical emergency. Prospective assessment of such patients into low risk and higher risk group, help in better patient management and better outcome. The current study evaluated the...
Comparison of Diagnostic Efficacy of Cholinesterase Levels to Differentiate Pleural Exudates and Transudates that of Lights Criteria
Abstract: Pleural effusion is a common clinical condition faced in everyday practice. The first step in the management of pleural effusion is its differentiation into transudates and exudates. Light’s criteria is the mos...
A Comparative Study to Find the Maternal and Foetal Outcome among Pregnancy Induced Hypertension and Non–Pregnancy Induced Hypertnsion Gravid Women
Abstract: Hypertension is the most common medical problem encounted in pregnancy and remains an important cause of maternal and foetal mortality and morbidity. The aim of the study were to...