Study of Cardiac Autonomic Neuropathy and Its Association with Qtc Dispersion in Type-2 Diabetes Mellitus Patients Attending Rural Medical College
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 6
Abstract
Abstract: The prevalence of diabetes is on the rise, ranked seventh among leading cause of death. One of the major reasons for death among diabetes patient is cardiac autonomic neuropathy. Studies have found that QTc dispersion is an early predictor of cardiac autonomic neuropathy in diabetes, this study was designed to evaluate the association between cardiac autonomic neuropathy with QTc dispersion to improve our knowledge in this area. To evaluate the presence of cardiac autonomic neuropathy in Type 2 diabetes and to co relate autonomic dysfunction. Five standard cardio vascular response tests were carried out (i.e. Valsalva ratio, expiration inspiration ratio, immediate heart rate response to standing, fall in systolic pressure on standing and sustained hand grip test) to determine the severity of cardiac autonomic neuropathy by scoring system. QTc dispersion was determined by subtracting heart rate- corrected minimum QTc interval (QTc min) from maximum QT interval (QTc max) from standard electrocardiogram. Cardiac autonomic neuropathy was studied in 50 diabetic patients and was compared with 50 age and sex matched controls. 17 patients had evidence of cardiacautonomic neuropathy. The diabetics had statistically significant cardiac autonomic neuropathy compared to controls. QTc dispersion was prolonged in 9 patients out of 17 who had cardiac autonomic neuropathy. QTc dispersion was statistically significant in diabetes with cardiac autonomic neuropathy in comparison to those without cardiac autonomic neuropathy. This study has taken-up a large number of diabetic patients for the evaluation of cardiac autonomic dysfunction and for evaluation of relationship between cardiac autonomic neuropathy and QTc dispersion. The incidence of cardiac autonomic neuropathy in this study was 34%. Cardiovascular autonomic neuropathy is a common complication of diabetes mellitus. Prolonged QTc dispersion is common in patients with autonomic dysfunction due to diabetes. The QTc dispersion associated significantly with presence of cardiac autonomic neuropathy and may be simple and useful measure for detection of cardiac autonomic neuropathy.
Authors and Affiliations
Dr. Mahantesh Ghaniger, Dr. Brijesh K
Keywords
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