Effect of Telmisartan on Learning and Memory in Albino Rats
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 3
Abstract
Abstract: Dementia is a syndrome of gradual onset and continuous decline of higher cognitive function. By 2050, more than 115 million people will have dementia. The prevalence of dementia rapidly increases from about 2-3% among those aged 70–75 years to 20–25% among those aged 85 years or more. Etiology of dementia is Alzheimer’s disease (AD), vascular dementia, and other neurodegenerative disease. Discovery of complete Renin angiotensin system (RAS) in the brain, and Potential function of Ang II in the etiology of certain neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, seizures, and the development of metabolic syndrome and diabetes. Telmisartanpossess partial peroxisome proliferators’ activator receptor gamma (PPAR) agonistic activity. PPAR-γ agonists have been reported to effectively attenuate oxidative stress, inflammation and apoptosis in the central nervous system (CNS). Wister albino rats weighing between 150-250 grams were taken for the present study. Rats were divided in five different groups, six animals in each group. The groups were as follows Group A was placebo (1% gum acacia) treated, Group B was treated with telmisartan, Group C was treated with donepezil, and Group D was treated with scopolamine, and Group E telmisartan and scopolamine. Drugs were given for a period of 20 days. The Morris Water Maze Test was carried out from 15th to 20th day. Time taken by the rats to find the hidden platform was defined as “Escape Latency” was recorded. Data were expressed as mean±standard deviation. Statistical difference between the experimental groups was determined by one-way ANOVA. The rate of learning and the extent of memory retention were different in different groups. This may be due to the nature of the drug given to these groups. Telmisartan have markedly improved learning and memory in rats as compared to control. Donepezil caused more improvement when compared to Telmisartan.
Authors and Affiliations
Uma Shanker Prasad Keshri, Sumit Kumar Mahato, Manju Gari, Akhilesh Kumar, Rajiv Kumar
Keywords
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