Topological Modeling of 1H-indole-2,3-dione Analogues as in vitro anti-cancer agents
Journal Title: Scholars Academic Journal of Pharmacy - Year 2015, Vol 4, Issue 5
Abstract
Abstract: QSAR analysis on a set of synthesized 1H-indole-2, 3-dione Analogues tested fir growth inhibitory anticancer activity was performed by using MLR procedure. The activity contributions of these compounds were determined from regression equation and the validation procedures to analyze the predictive ability of QSAR models were described. .The results are discussed on the basis of statistical data. High agreement between experimental and predicted anticancer activity inhibitory values is obtained. The results of this study indicate that the substitution of electron withdrawing group, aromatic ring, polarizablity, etc. parameters has a significant effect on anticancer activity of this class of compounds, thus simplifying design of new biological active molecule. Keywords: QSAR, anticancer activity, in vitro studies.
Authors and Affiliations
Shailja Sachan, Santosh Kumar Tiwari, Kamlesh Mishra, Śantosh Tiwari, Vikash Pandey
Keywords
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