Topological Modeling of 1H-indole-2,3-dione Analogues as in vitro anti-cancer agents
Journal Title: Scholars Academic Journal of Pharmacy - Year 2015, Vol 4, Issue 5
Abstract
Abstract: QSAR analysis on a set of synthesized 1H-indole-2, 3-dione Analogues tested fir growth inhibitory anticancer activity was performed by using MLR procedure. The activity contributions of these compounds were determined from regression equation and the validation procedures to analyze the predictive ability of QSAR models were described. .The results are discussed on the basis of statistical data. High agreement between experimental and predicted anticancer activity inhibitory values is obtained. The results of this study indicate that the substitution of electron withdrawing group, aromatic ring, polarizablity, etc. parameters has a significant effect on anticancer activity of this class of compounds, thus simplifying design of new biological active molecule. Keywords: QSAR, anticancer activity, in vitro studies.
Authors and Affiliations
Shailja Sachan, Santosh Kumar Tiwari, Kamlesh Mishra, Śantosh Tiwari, Vikash Pandey
Keywords
Related Articles
- EP ID EP377386
- DOI -
- Views 75
- Downloads 0
GC Determination of Docosahexaenoıc Acid, Eıcosapentaenoic Acid and Other Fatty Acids in food Supplements by Percentage Method
Abstract: The aim of current study was the application of GC method for separation of Docosahexaenoic acid and Eicosahexaenoic acid from other fatty acids in food supplements and their further determination by percentag...
Inhibition of Matrix Metalloproteinase-2 Expression by Ethanolic Extracts of Zingiberaceae Rhizomes in Artery Endothelial Cells
Atherosclerosis belongs to inflammation-related vascular diseases due to bacterial infection and causes lipid accumulation in artery wall that lead to heart attack and stroke. Matrix metalloproteinase (MMP)-2 and -9 are...
Knowledge, Attitude and Practice of Emergency Contraceptives Among Graduating Female Students of College of Health and Medical Sciences, Haramaya University, Eastern Ethiopia
Abstract:Emergency contraception refers to a method that women can use to prevent pregnancy after unprotected sexual intercourse, method failure or incorrect use. Unwanted pregnancy followed by unsafe abortion can be avo...
Antidiarrheal and Antimicrobial Activities of Ethno Medicinal Plant: Mikania scandens (L) Willd
Abstract: The aim of the present study was carried out to investigate the antidiarrheal and antimicrobial potential of both ethanol and aqueous extracts of aerial parts of Mikania scandens .In vivo Antidiarrheal activity...
Saxagliptin versus Glimepiride Combination with Metformin in Type 2 Diabeted Mellitus
Abstract: Various groups of oral hypoglycemic agents (OHAs) are recently available, but there is a need for agents with different mechanisms of action that achieve better efficacy and can be used either as monotherapy or...