Selectivity of Plant and Microbial Mediated Reduction of Ketones
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 1
Abstract
Abstract: Bioreduction of ketones is an alternative tool for the synthesis of enantiomeric alcohols. Biocatalytic reduction of acetophenone and its derivatives have been widely reported. Some of the microorganisms obtained from culture collection centre as well as those isolated in our microbiology lab and few plant tissues obtained from local market were screened for their potential and performance in reduction of p-chloroacetophenone and dimethoxy indanone. The parameters such as pH, temperature, substrate concentration and incubation time were evaluated during optimization. Aspergillus flavus, Aspergillus niger, Aspergillus ocraceae showed significant bioconversion. Aspergillus flavus showed maximum ability of bioreduction, it was considered for optimization. Among the screened plant tissues, used for the reduction p-chloroacetophenone, radish showed significant bioconversion. The maximum reduction was observed with Onion and the least with Beetroot.
Authors and Affiliations
Sushma KR, Kalpana Divekar, Mahesh AR
Keywords
Related Articles
- EP ID EP479909
- DOI -
- Views 78
- Downloads 0
Antimicrobial activity and Characterization of Marine bacteria in Coastal sea water
Coastal seawater samples were collected from Rameswaram, Ramanathapuram District. Twenty five bacteria were isolated and identified according to morphology, biochemical tests and selective growth media. The active marine...
Scrub Typhus-Varied Presentation
Scrub typhus is an acute febrile illness caused by mite-borne Gram-negative bacterium Orientia tsutsugamushi. We report a case of Multi organ dysfunction syndrome admitted in Intensive care unit and was diagnosed with Sc...
Antidiarrheal and Antimicrobial Activities of Ethno Medicinal Plant: Mikania scandens (L) Willd
Abstract: The aim of the present study was carried out to investigate the antidiarrheal and antimicrobial potential of both ethanol and aqueous extracts of aerial parts of Mikania scandens .In vivo Antidiarrheal activity...
Antioxidant and Anti-Inflammatory Activity of Proteins Isolated From ZingiberOfficinaleRoot
To investigate the in vitro, antioxidant and anti-inflammatory activity of the proteins isolated fromZingiberofficinale, proteins isolated by Ammonium sulphate precipitation method. In vitro antioxidant studies were carr...
Determination of Sildenafil Citrate in Powder Preparations Prepared from Revatio Tablets 20 mg for Infants with Persistent Pulmonary Hypertension of the Newborn
The aim of the present study was to develop and validate a HPLC method for the assay of sildenafil citrate (SIL) in powder preparations prepared from Revatio Tablets 20 mg for infants with persistent pulmonary hypertensi...