Selectivity of Plant and Microbial Mediated Reduction of Ketones
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 1
Abstract
Abstract: Bioreduction of ketones is an alternative tool for the synthesis of enantiomeric alcohols. Biocatalytic reduction of acetophenone and its derivatives have been widely reported. Some of the microorganisms obtained from culture collection centre as well as those isolated in our microbiology lab and few plant tissues obtained from local market were screened for their potential and performance in reduction of p-chloroacetophenone and dimethoxy indanone. The parameters such as pH, temperature, substrate concentration and incubation time were evaluated during optimization. Aspergillus flavus, Aspergillus niger, Aspergillus ocraceae showed significant bioconversion. Aspergillus flavus showed maximum ability of bioreduction, it was considered for optimization. Among the screened plant tissues, used for the reduction p-chloroacetophenone, radish showed significant bioconversion. The maximum reduction was observed with Onion and the least with Beetroot.
Authors and Affiliations
Sushma KR, Kalpana Divekar, Mahesh AR
Keywords
Related Articles
- EP ID EP479909
- DOI -
- Views 106
- Downloads 0
Development of Interpenetrating Polymer Networks of Chitosan and Guar Gum for Propranolol Hydrochloride
Abstract: The purpose of this study was to develop a Interpenetrating Polymer Network (IPN) of Chitosan and Guar gum. The drug Propranolol HCl, a calcium channel blocking agent used in the treatment of angina pectoris, h...
Polymers in Drug Delivery Technology, Types of Polymers and Applications
Abstract:Polymers play a major role in the development of drug delivery technology by release of two types of drugs like hydrophilic and hydrophobic. In a synchronized manner and constant release of formulations over ext...
Development and Validation of Visible Spectrophotometric Method for the Estimation of Lamivudine in Bulk and Pharmaceutical Dosage Form
A Simple, accurate, precise and economical procedure was developed for UV Spectroscopic estimation of Lamivudine in pure state and in its pharmaceutical formulation. The developed method is based upon complex formation o...
Characteristic Analysis of Crude and Purified α-amylase from Bacillus licheniformis ATCC 6346 and comparison with Commercial enzyme
Abstract: Thermostable -amylases are generally used for industrial applications. The objective of this study is to compare the kinetic properties of crude and purified -amylase from Bacillus licheniformis ATCC 63...
Overview of Validation and Basic Concepts of Process Validation
Quality is the primordial intention to any industry and its products manufactured. Multiple views on obtaining such quality are the current interest in the pharmaceutical industry. Validation is the art of designing and...