Effect of Terminalia bellerica against high fat diet induced hyperlipidemia and obesity
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 4
Abstract
Present study was focused to investigate the anti-hyperlipidemic activity of Terminalia bellerica against high fat diet induced hyperlipidemia and obesity. Terminalia bellerica commonly known as Baheda is one of the most common plants being used in India since early times in many disorders one of the ingredients in many polyherbal formulations like Triphala etc used for cardiac disorders. The ethanolic extract of the fruits of Terminalia bellerica 250mg/kg & 500mg/kg body weight was administered p.o. for 20 days to test antihyperlipidemic activity. The parameters for evaluation of anti-hyperlipidemic activity are the physical parameters and the biochemical estimations. The physical parameters were gross examination of heart, heart weight: body weight ratio, liver weight, atherogenic index and basal metabolic index. In biochemical estimations various cardiac enzymes like lactate dehydrogenase, and the lipid profile were measured. The results of present study show that alcoholic extract of Terminalia bellerica (500 mg/Kg) has significant reduction in various lipid levels as well as the elevated physical parameters like heart weight: body weight ratio, body weight gain and BMI against high fat diet induced hyperlipidemia and obesity compared to clinically used drugs, Atorvastatin (10mg/kg) and Orlistat (pure drug 10mg/kg).
Authors and Affiliations
Pragya Misra
Keywords
Related Articles
- EP ID EP197586
- DOI -
- Views 82
- Downloads 0
Hospital Infection Control:Intensive Care Unit as an indicator
Introduction: The Hospital Infection Control Committee (HICC) has an arduous role in a tertiary care hospital where lapses in infection control measures can adversely impact patient morbidity and survival. Outbreaks of e...
The relationship among mitochondrial dysfunction and antibiotic activities on Toxoplasma gondii in vitro
Toxoplasma gondii is the causative agent of toxoplasmosis, which current chemotherapies are self-limiting due to inability to eliminate the parasite and induce toxic effects. Then, new therapies are necessary and antibio...
Therapeutic Approach to Reduce Cardiovascular Risk by Modulating Immune Function and Inflammatory Process
The aim of this study is to prevent the severity of psoriasis disease and cardiovascular risk by modulating the immune function and inhibiting the inflammatory process by a novel drug Atorvastatin. Inflammation is a prim...
Cytotoxicity and apoptosis of glioblastoma multiforme cell line by arginine deiminase purified from a higher productive isolation Enterococcus faecium M1
Purified arginine deiminase from Enterococcus faecium M1 isolate is the strongest cancer treatment enzyme due to its activity and stability in different environmental conditions. The cytotoxicity of ADI to glioblastoma m...
Assessment of row wise attention capacity of students to a standard lecture class
Present curriculum in teaching and learning is, focused more on student centered techniques. We believe in, that students sitting in front rows are attentive and girls performing greater than boys. To evaluate whether ro...