Effect of Terminalia chebula and Gallic Acid on Increased Adiposity of High-Fat Diet Induced Hyperlipidemic Mice
Journal Title: International Journal of Current Research and Review - Year 2018, Vol 10, Issue 10
Abstract
Objective: To elucidate the role of Terminalia chebula and Gallic Acid on increased adiposity and as a regulator of Lipogenesis and its associated factors in high-fat diet induced hyperlipidemic mice. Methods: The study was performed on C57BL/6J Male mice aged 6-8 weeks. Control was fed with normal diet and the other 3 groups were fed with commercial hyperlipidemic diet. Adipose tissue markers Peroxisome proliferator-activated receptorgamma, CCAAT/enhancer-binding proteins-beta, 4-Hydroxy-2-nonenal, Thioredoxin, Tumour necrosis factor-α, adiponectin and leptin were estimated using adipose tissue by ELISA. Results: The diet-induced hyperlipidemic C57BL/6J Male mice showed a marked reduction in the levels of transcription factors, oxidative stress markers and pro-inflammatory markers when treated with Terminalia chebula (Peroxisome proliferator-activated receptor-gamma (P<0.001),CCAAT/enhancer-bindingproteins-beta(P<0.001),4-Hydroxy-2-nonenol(P<0.001), Thioredoxin (P<0.01) and Tumour necrosis factor-α (P<0.001) which was more effective than Gallic Acid(Peroxisome proliferator-activated receptor-gamma(0.05),CCAAT/enhancer-binding proteins-beta(P<0.01), 4-Hydroxy-2-nonenal (P<0.01), Thioredoxin(P<0.05) and Tumour necrosis factor-α (P<0.01) and an elevation in adipokines- adiponectin and leptin in Terminalia chebula treated group- adiponectin (P<0.001)and leptin (P<0.001) was seen which was more significant than Gallic Acid- adiponectin (P<0.01) and leptin (0.05) when compared to group II HFD. Conclusion: The study indicates the efficacy of Terminalia chebula as a potent antihyperlipidemic herbal drug which helps in controlling the increased adiposity by regulating the key markers in adipose tissue.
Authors and Affiliations
Padmini E.
Keywords
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- EP ID EP542722
- DOI 10.31782/IJCRR.2018.10107
- Views 119
- Downloads 0
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