Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context
Journal Title: Iranian journal of diabetes and obesity (IJDO) - Year 2022, Vol 14, Issue 3
Abstract
Objective: Diabetes mellitus (DM) is known as the silent pandemic. It is hypothesized that other endocrine systems are affected by the metabolic changes occurring due to DM. We aimed to investigate the correlation of thyroid hormones with glycaemic and lipid parameters. Materials and Methods: 81 diabetic patients and 81 non-diabetic age and sex-matched healthy volunteers participated in the study. Their blood samples were analysed for fasting blood glucose (FBG), glycosylated haemoglobin (HbA1C), total tri-iodothyronine (T3), total thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid-stimulating hormone (TSH), total cholesterol (CHOL), High-Density-Lipoprotein cholesterol (HDLC) and Low-Density-Lipoprotein cholesterol (LDLC). Data was analysed using appropriate statistical tests. Results: Among the cases, 70.37% were euthyroid, while 24.7% had subclinical hypothyroidism, 2.47% had clinical hypothyroidism, 1.23% had subclinical and 1.23% had clinical hyperthyroidism. FBG, HbA1c and TSH (P< 0.05) were significantly higher in diabetics compared to controls. On the other hand, T3, FT3, FT4, and HDLC (P< 0.05) were significantly lower in diabetics compared to controls. A significant negative correlation (P< 0.05) was found when T3 and FT3 were compared against age, FBG and HbA1c. A significant positive correlation (P< 0.05) was found when T3 and FT3 were compared against HDLC, LDLC & CHOL. Conclusion: Our statistics show that high-normal levels of T3 and FT3 are correlated with lower levels of FBG and HbA1c, hence improved glycaemic control. We recommend that thyroid profile of diabetic patients with poor control should be monitored regularly. Early detection of thyroid dysfunction and initiation of therapy for it, can improve the treatment outcome of hypoglycaemic drugs.
Authors and Affiliations
Vatsal Navin Jain,Swati Ghanghurde,Sherwin Rajesh Carvalho,Shivani Sachin Nirgudkar,Mohit Vijay Rojekar,
Keywords
Related Articles
- EP ID EP709415
- DOI -
- Views 54
- Downloads 0
Yoga-based Mindfulness Training as an Intervention for the Reduction of Symptoms of Anxiety and Depression in Children and Adolescents with Type 1 Diabetes
Objective: Yoga has also been implemented in healthcare institutions to manage disease-sequelae, including pain, anxiety, depression, fatigue, and insomnia. In this study, we aimed to evaluate the effect of Yoga-based mi...
Self-Compassion Reduces the Destructive Effects of Perceived Stress on Psychological Well-Being and Self-Care Behaviors: Results from Type II Diabetes Mellitus Patients
Objective: This study investigated the mediating role of self-compassion in the relationship of perceived stress with physiological well-being and self-care behaviors among patients suffering from type II diabetes mellit...
Correlation between Circulating Endothelial Progenitor Cell Markers, Vitamin D, and Iron Levels in Diabetic Nephropathy
Objective: Circulating endothelial progenitor cells (EPCs) play an essential role in endothelial repair and neovascularization. Vitamin D deficiency may contribute to EPC depletion and endothelial dysfunction in patients...
The Impact of HIIT on the cTnT Response in Sedentary Obese Young Men
Objective: Evaluation of the effect of 8 weeks of High-Intensity Interval Training (HIIT) on the serum level of cardiac troponin T (cTnT) in sedentary obese young men. Materials and Methods: Thirty sedentary men were ra...
Predicting Women\'s Marital Adjustment based on Attitudes toward Infidelity, Health Literacy and Self-Care in their Diabetic Spouses in Ahvaz
Objective: The aim of this study is to employ an artificial neural network to predict the marital adjustment of women by investigating their attitudes toward infidelity, health literacy, and self-care concerning their di...