The Effect of Endurance Training on Expression of Autophagy Genes (Beclin-1, ULK-1) in the Heart Tissue of Male Rats with Experimental Diabetes
Journal Title: Iranian journal of diabetes and obesity (IJDO) - Year 2022, Vol 14, Issue 1
Abstract
Objective: This study aimed to investigate the effect of six weeks of endurance training on the expression of autophagy-related genes (Beclin-1, ULK-1) in the heart tissue (Myocardium) of rats with diabetes. Materials and Methods: Twenty male wistar rats (weight: 204±11.3g), (age= 8 weeks) were divided into four groups including: 1) diabetic type1 training, group 2) diabetic type1 control, group 3) healthy training group, and 4) healthy control group. They developed diabetes by intraperitoneal injection of streptozotocin (STZ) (45 mg / kg). The endurance training was performed with a moderate intensity (50-55% vo2max) of 5 days a week for 6 weeks. The expression level of autophagy-related genes (ULK-1, Beclin-1) was measured by real-time technique. One-way analysis of variance and Tukey's post hoc test were used for statistical analysis. Results: The expression of autophagy genes (Beclin-1: diabetic type1 control group: 2.49 (±0.53), and healthy control group: 1 (±0.21)), (ULK-1; diabetic type1 control group: 2.56 (±1.02), and healthy control group: 1 (±0.35)) in heart tissue in diabetic rats was significantly higher than in the healthy control group (P: 0.001). After six weeks of endurance training, the expression of these genes in heart tissue was significantly lower in the diabetic training group, healthy training and healthy control than in the diabetic control group. (P: 0.001). Conclusion: The present study results showed that endurance training by reducing autophagy factors in the heart of male rats with diabetes could be helpful as a preventive and non-pharmacological agent in the treatment of diabetic patients.
Authors and Affiliations
Masoumeh Hosseinzadeh,Asma Taheri,
Keywords
Related Articles
- EP ID EP700565
- DOI 10.18502/ijdo.v14i1.8742
- Views 74
- Downloads 0
Lived Experiences of Type 2 Diabetes with Irreversible Complications: A Qualitative Research
Objective: Diabetes is a major health concern worldwide. Diabetic patients experience many issues that affect their lives. Poor self-care and compliance in type 2 diabetes mellitus (T2DM) patients cause chronic hyperglyc...
Common Polymorphisms Identified In Patients with Type 2 Diabetes Mellitus Revealed From Next-Generation Sequencing Analysis
Objective: Type 2 diabetes mellitus (T2DM) is a multifactorial genetic condition caused by the combination of genes and environmental factors. Several variations linked to T2DM have been discovered in recent genetic inve...
The Trends of Prevalence of Obesity in Turkey From 2008-2016
Objective: Obesity is one of the major public health problems in Turkey and worldwide. This study was conducted to determine the trends of the obesity prevalence in Turkey from 2008 to 2016 by analysing sociodemographic...
Access to Anti-Diabetic Medicines among Patients Attending TertiaryHealth Facilities in Oyo State, Nigeria
Objective: The management of Diabetes Mellitus (DM) is longterm and can be expensive. This study aimed to describe access to anti-diabetic medicines among patients in tertiary health care facilities in Oyo State, Nigeria...
First Trimester Potential Biochemical Predictive Tests for Gestational Diabetes Mellitus: A Systematic Review
Objective: Gestational diabetes mellitus (GDM) is the most common metabolic complication during pregnancy. So, a large number of studies have evaluated the usefulness of different screening tests. The aim of this study w...