EFFECT OF THYROTROPIN SUPPRESSION LEVEL ON DIASTOLIC HEART FUNCTIONS IN PATIENTS WITH DIFFERENTIATED THYROID CANCER
Journal Title: Kocatepe Medical Journal - Year 2024, Vol 25, Issue 4
Abstract
OBJECTIVE: The aim of this study was to investigate the changes in cardiac structure and diastolic functions according to thyroid-stimulating hormone (TSH) suppression treatment degree in patients with differentiated thyroid cancer (DTC). MATERIAL AND METHODS: This cross-sectional study included 125 patients with DTC who were being followed in the endocrinology clinic of our hospital and had been receiving thyroid hormone replacement and TSH suppression therapy for more than one year following thyroid surgery. In our study, patients were divided into groups based on the American Thyroid Association (ATA) 2015 guideline risk assessments. The patients were divided into three groups: first group patients with TSH levels <0.1 mIU/L (n=30), second group those with TSH levels between 0.1-0.5 mIU/L (n=56), and third group those with TSH levels between 0.5-2 mIU/L (n=39). The first two groups were classified as suppression groups, and the third as replacement (control) group. All patients underwent M-mode and pulse-vave tissue doppler echocardiography. RESULTS: The group 1 with TSH interval <0.1 mIU/L had significantly longer left ventricular end-diastolic diameter (EDD) than the replacement group (45.35±3.54 vs. 42.74±6.08; p=0.016). E velocity, which measures mitral valve velocity at early diastolic filling, was found to be significantly lower in group 1 than in the replacement group (0.7(0.6-0.8) and 0.84(0.7-0.98); p=0.010). The groups did not differ in terms of A, E' velocities, or E/A ratio. CONCLUSIONS: In patients receiving TSH suppression therapy for differentiated thyroid cancer, changes in myocardial structure and function may vary depending on the level of TSH suppression, even if clinical symptoms are absent. Cardiac evaluations are critical for early detection of diastolic dysfunction, particularly in the high-risk DTK group. Follow-up of patients receiving TSH suppression should not be interrupted, and suppression levels should be adjusted individually.
Authors and Affiliations
Ziynet ALPHAN UC, Semih ÇELİK, Özkan CANDAN
Keywords
Related Articles
- EP ID EP759923
- DOI https://doi.org/10.18229/kocatepetip.1445719
- Views 22
- Downloads 0
COMPARING INPATIENT REHABILITATION AND HOME-BASED REHABILITATION PRACTICES FOLLOWING ACUTE STROKE: A PROSPECTIVE CONTROLLED STUDY
OBJECTIVE: The aim of this study is to evaluate whether home-based rehabilitation (HBR) is as effective as inpatient rehabilitation in patients with acute stroke as well as to identify patients at increased risk of morta...
EVALUATION OF ADULT PATIENTS' ATTITUDES AND BEHAVIORS ABOUT INFLUENZA, PNEUMOCOCCAL, HERPES ZOSTER AND TETANUS VACCINES: A SINGLE-CENTER SURVEY STUDY
OBJECTIVE: The key component of preventive health care is adult immunization. The aim of this study was to assess the patients’ knowledge about adult vaccination and the vaccination rates of patients admitted to the fami...
PREOPERATIVE EVALUATION OF LIVING DONOR KIDNEY VARIATIONS WITH MULTIDETECTOR COMPUTED TOMOGRAPHY AND COMPARISON OF RESULTS WITH INTRAOPERATIVE FINDINGS
OBJECTIVE: The aim of this study was to evaluate the renal vascular and collecting system variations in living kidney donors using multidetector computed tomography (MDCT) and to compare the data with the findings detect...
SERUM SCLEROSTIN AND DICKKOPF-1 LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME
OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in premenopausal women, and it is a complex syndrome affecting various systems. Numerous studies have been carried out, on the effects of...
EXAMINATION OF "DENS" TERMS USED INDEPENDENTLY OF TOOTH STRUCTURE IN THE ANATOMY LITERATURE
OBJECTIVE: EThe word "dens", which is used as an anatomy term, is often used beyond its primary meaning of "tooth." In this study, it is aimed to examine the Latin terminology of dens terms used in contexts other than it...