Effect of TonEBP on cardiovascular manifestations; influence of signaling mediators
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 5
Abstract
Tonicity-responsive enhancer binding-protein (TonEBP or NFAT5), which belongs to the Rel/NFAT family of transcription factors, plays a critical role in the kidney by controlling the expression of osmoprotective genes including heat-shock protein 70 and genes that mediate the intracellular accumulation of small organic osmolytes that reduce intracellular ionic strength without affecting protein function, such as aldose reductase (AR), sodium-chloride-betaine cotransporter (BGT1), and sodium-myo-inositol cotransporter (SMIT). Numerous cell types throughout the body are exposed to aniosmotic environments. Environmental osmolality is greatest in the kidney where levels as high as 1200 mOsmol/kg can be reached at the tip of the inner medulla in humans. This review examines the importance of TonEBP on cardiovascular manifestations and influence of signaling molecules.
Authors and Affiliations
Manoj G Tyagi, Pulastya Vora, K N Anand, Aniket Kumar
Keywords
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