Effect of tramadol in elevated plus maze apparatus– A rodent model of anxiety
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2015, Vol 3, Issue 4
Abstract
Anxiety is a widespread disorder in world wide. Some amount of anxiety always associated with depression. In this study we tested anti-anxiety effect of tramadol in Elevated plus Maze apparatus (EPM). Tramadol is a synthetic centrally acting opioid analgesic. It is a weak µ opioid receptor agonist and also act as an anti-depressant by inhibiting uptake of noradrenaline and serotonin. Rats (150-250g) of either sex were randomly divided into 4 groups of 6 animals each. Tramadol was administered at two different doses (20, 40 mg/kg, i.p) 30 mints before conducting test. No of entries and time spent in both closed and open arm observed. The antianxiety effect of tramadol was compared to that of diazepam (2 mg/kg, i.p), in elevated plus maze apparatus (EPM).The result of the study shows that tramadol dose dependently increases entries and time in open arm (40mg/Kg) in EPM. Tramadol showed anti-anxiety activity in Elevated Plus Maze apparatus.
Authors and Affiliations
Jayasree D*| Asst. Professor, Dept. of Pharmacology, Madha Medical College & Research Institute, Porur, Chennai-600112, Tamil Nadu, India., Rajeswaramma G| Asst. Professor, Dept. of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.
Keywords
Related Articles
- EP ID EP1619
- DOI -
- Views 401
- Downloads 22
PREPARATION AND EVALUATION OF NANOSUSPENSION OF POORLY SOLUBLE DRUG ALBENDAZOLE
The aim of the present work was to enhance solubility of albendazole a class II drug by nanosuspension technology. Nanosuspensions are prepared by using wet mill, high pressure homogenizer, emulsion‐solvent diffusion, me...
A study on nutritional status of adolescent girls with reference to BMI among school going adolescent girls, Chidambaram.
Introduction: Adolescence is a crucial period of important distinctions together with physiological, physical, behavioral and social changes. Under-nutrition among adolescent girls is a major public health problem unsoun...
COMPARISON OF ERYTHROPOIETIN AND DARBEPOETIN IN CHRONIC KIDNEY DISEASE PATIENTS IN A TERTIARY CARE HOSPITAL
Chronic kidney disease (CKD), is a progressive loss of kidney function over several months to years and cause complications like anaemia. Erythropoiesis stimulating agents (ESAs) such as erythropoietin and darbepoetin a...
Knowledge, attitude and practice of medicated contraception among females of reproductive age group
Lack of knowledge of contraception has lead to increased maternal mortality, morbidity due to unsafe abortion. Hence our study was aimed to determine knowledge, attitude and practice of contraception and impact of socio...
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF NOVEL SERIES OF BIS-IMIDAZO[1,2-a]PYRIDINE DERIVATIVES
imidazo[1,2-a]pyridine. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has b...