Effect of treatment with N-acetylcysteine on non-enzymatic antioxidant reserves and lipid peroxidation in workers exposed to lead

Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 21, Issue 2

Abstract

There are no published studies examining the effects of N-acetylcysteine (NAC) administration on the non-enzymatic defence systems in humans exposed to lead. In view of this, it was decided to measure the levels of uric acid (UA), albumin, bilirubin and alpha-tocopherol before and after treatment with NAC. An estimation was also made of the degree of oxidative stress by measuring the ferric reducing ability of plasma (FRAP), the levels of conjugated dienes (CD) and lipid hydroperoxides (LHP). Male employees who worked with lead were randomized into two groups. The first group included workers who were not administered any drugs (n=49), while the second group (n=122) consisted of workers who were treated with NAC at three different doses (200 mg, 400 mg and 800 mg) for 12 weeks. The administration of NAC (400 mg, 800 mg) resulted in significant decreases in the LHP levels. Similarly, a strong tendency toward lower levels of CD was observed in the same groups. The UA levels were significantly lower only in the group receiving the 200 mg dose of NAC. However, the alpha-tocopherol levels were significantly elevated after treatment with NAC (400 mg, 800 mg). NAC administration did not significantly affect the levels of bilirubin and albumin, but a tendency toward higher values was observed for FRAP. NAC reduced the extent of lipid peroxidation in a dose-dependent manner. Elevated concentrations of alpha-tocopherol may have enhanced the beneficial effects of NAC. Treatment with NAC may contribute to the restoration of non-enzymatic antioxidant reserves when administered to lead-exposed workers.

Authors and Affiliations

Sławomir Kasperczyk, Michał Dobrakowski, Aleksandra Kasperczyk, Jolanta Zalejska-Fiolka, Natalia Pawlas, Lucyna Kapka-Skrzypczak, Ewa Birkner

Keywords

Related Articles

Prediction of biological sensors appearance with ARIMA models as a tool for Integrated Pest Management protocols

[b]Introduction and objectives.[/b] Powdery mildew caused by [i]Uncinula necator[/i] and Downy mildew produced by [i]Plasmopara viticola[/i] are the most common diseases in the North-West Spain vineyards. Knowledge of ai...

Diagnosis of hymenoptera venom allergy – with special emphasis on honeybee (Apis mellifera) venom allergy

Hymenoptera stings occur very frequently and usually are not dangerous. The normal reaction after sting includes such symptoms as: mild swelling, redness and pain lasting from several minutes to several hours. In contras...

Efficacy and safety of insulin pump treatment in adult T1DM patients – influence of age and social environment

Introduction and objective. Continuous subcutaneous insulin infusion (CSII) via personal insulin pump is a valuable therapeutic tool in T1DM patients. However, adherence to recommended CSII- related behaviours may be of...

Progress in the molecular methods for the detection and genetic characterization of Cryptosporidium in water samples.

Cryptosporidium, the protozoan parasite, has several transmission routes, including anthroponotic and zoonotic transmission, as well as the foodborne way, but mainly by water. The oocysts, the resistant stage produced by...

Cardiac rehabilitation: a good measure to improve quality of life in peri- and postmenopausal women with microvascular angina

Cardiac Syndrome X (CSX) was considered a stable coronary syndrome, yet due to its nature, CSX symptoms often have a great impact on patients’ Quality of Life (QoL). According to ESC 2013 stable coronary artery disease c...

Download PDF file
  • EP ID EP80778
  • DOI -
  • Views 120
  • Downloads 0

How To Cite

Sławomir Kasperczyk, Michał Dobrakowski, Aleksandra Kasperczyk, Jolanta Zalejska-Fiolka, Natalia Pawlas, Lucyna Kapka-Skrzypczak, Ewa Birkner (2014). Effect of treatment with N-acetylcysteine on non-enzymatic antioxidant reserves and lipid peroxidation in workers exposed to lead. Annals of Agricultural and Environmental Medicine, 21(2), 272-277. https://europub.co.uk/articles/-A-80778