Effect of Trifluoromethyl Substitution on C-3 Position in 1H NMR of Quinolones / Coumarins
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 8, Issue 3
Abstract
The structural assignment of differently substituted quinolones / coumarins was reviewed using 1H NMR spectral data. In case of quinolones / coumarins, with varied substitutions at C-4 and different positions of the benzenoid ring, there is a great variation in the 1H NMR value of the proton only attached with C-3. It was observed that when different substitutions (methyl / amino / hydroxy / acetoxy / trifluoromethyl) were carried out at C-4 position, maximum deshielding with the proton attached with C-3 was observed with trifluoromethyl substitution. The observation is same even with the variation in different groups at the benzenoid ring.Â
Authors and Affiliations
Anjali Gupta, Rajinder K. Gupta
Keywords
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- EP ID EP652661
- DOI 10.24297/jac.v8i3.4053
- Views 161
- Downloads 0
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