EFFECT OF VARIOUS VEGETABLE OILS ON THE LIPID PROFILE AND ANTIOXIDANT STATUS IN HYPERCHOLESTEROLAEMIC WISTAR RATS- A COMPARATIVE STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 14
Abstract
BACKGROUND Various vegetable oils are used for cooking foods in India. Controversies have been created that consumption of certain vegetable oils cause atherogenesis. A little is known about the effect of vegetable oils in hypercholesterolaemic conditions. Hypercholesterolaemia, mainly the increased plasma Low-Density Lipoprotein (LDL) cholesterol levels and Reactive Oxygen Species (ROS) has been implicated in the early development and progression of atherosclerosis and Coronary Heart Diseases (CHD). Current study is designed to assess the effect of various vegetable oils such as coconut, sunflower, palm, olive oil and vanaspati on lipid profile and oxidative stress parameters in rats fed on a high-cholesterol diet. MATERIALS AND METHODS Hypercholesterolaemia is induced by supplementing cholesterol with the basal diet. Reference dose of various vegetable oils were administered once daily for 90 days. After the treatment period of 90 days, triacylglycerol, total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol and oxidative stress parameters are estimated and analysed. RESULTS In the present study, we observed the lipid-lowering effect of various vegetable oils in rats fed with high-cholesterol diet. Administration of cholesterol showed increased level of lipid profile. Concurrent administration of various vegetable oils with high-cholesterol diet caused a significant decrease in serum total cholesterol, LDL and VLDL cholesterol. This conclusion is made based on the observation that the vegetable oils were able to restore, at least partially, the lipid profile of hypercholesterolaemic rats. A decline of antioxidant status associated with an increase in lipid peroxidation was observed in all the vegetable oil treated groups. Among the oils, coconut oil showed a mild increase in High-Density Lipoprotein (HDL) and least increase in lipid peroxidation compared to other vegetable oils treated groups. CONCLUSION Results suggest that the addition of vegetable oils showed a positive influence on lipid metabolism in hypercholesterolaemic rats. Among the vegetable oils, coconut oil was found to be beneficial as it has more antioxidant property. These findings can provide useful information regarding the choice of vegetable oils in hypercholesterolaemic patients in future
Authors and Affiliations
Prasad Ravindra Manjeshwar, Urban D’Souza, Shankar Bhat, Kumar Megur Ramakrishna Bhat, Nayanatara Arunkumar
IMPACT OF HEALTH TALK ON THE KNOWLEDGE ABOUT MENSTRUAL HYGIENE AMONG SCHOOL GOING EARLY ADOLESCENT GIRLS
BACKGROUND Adolescence is a period of transition from childhood to adulthood. It is the period of life between ages of 10-19 years. Lack of knowledge and poor personal hygienic practices can lead to various gynaecologica...
INCIDENCE AND RISK FACTORS OF ROP IN A TERTIARY CARE CENTER IN WESTERN ODISHA: OUR EXPERIENCE SO FAR
BACKGROUND Retinopathy of prematurity (ROP) is a disorder of preterm infants in which the developing retinal blood vessels are not well developed which causes poor visual acuity or blindness. Blindness due to retinopathy...
ATYPICAL FABRY’S DISEASE
Fabry‟s disease (angiokeratoma corporis diffusa) is an X linked recessive lysosomal storage disorder caused by the deficiency of alpha galactosidase A (alpha gal A) which causes progressive accumulation of glycosphingoli...
A STUDY OF FETAL OUTCOME IN OLIGOHYDRAMNIOS (AFI BETWEEN 0-7)
OBJECTIVES: Amniotic fluid Volume (AFV) is an important indicator of fetal wellbeing Oligohydramnios affects 0.5 to 5% of the pregnancy. In presence of Oligohydramnios if the AFI is 0-7 the fetal outcome is not good. If...
COMPREHENSIVE STUDY OF HYDATID DISEASE OF LIVER AND MANAGEMENT AT PERIPHERAL TERTIARY CARE HOSPITAL
BACKGROUND Hydatid Disease (HD) is a zoonotic disease caused by the larvae of Echinococcosis granulosus, now become a rare clinical entity in teaching medical college hospitals. This is due to the public education about...