EFFECT OF VITIS VINIFERA AGAINST TRITON X 100 INDUCED HYPERLIPIDAEMIA IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
To evaluate the effect of Vitis vinfera fruit juice (VVFJ) against Triton X 100 induced hyperlipidaemia. Wister strain rats were treated with atorvastatin (ATOR-10mg/kg, p.o.), low and high dose of Vitis vinifera fruit juice (VVFJ- 100 and 500mg/kg) orally for 0, 24 and 44 hours after treated with Triton X 100 (400mg/kg, p.o). 4 hour after the last dose, blood was collected from all the animals and the separated serum was subjected for the estimation of serum lipoproteins level such as Triglycerides (TGs), Total cholesterol (TC), High density lipoprotein-cholesterol (HDL-c), Low density lipoprotein-cholesterol (LDL-c), Very low density lipoprotein (VLDL) and serum glucose level and atherogenic index. In hyperlipidemic control group Triton X 100 resulted in a significant increase in TG, TC, LDL, VLDL, atherogenic index and a significant decrease was found for HDL values compared with normal control. The treatment group of atorvastatin and Vitis vinifera fruit juice (100/500mg/kg, p.o.) showed significant decrease in TG, TC, LDL, VLDL, atherogenic index and serum glucose compared with hyperlipidemic control. Whereas for HDL values it was found to be a significant increase. The study revealed that atorvastatin, low dose and high dose of Vitis vinifera fruit juice (100/500mg/kg, p.o.) possess significant antihyperlipidemic activity. Among all treated group high dose of Vitis vinifera fruit juice found to be more effective against Triton X 100 induced hyperlipidaemia.
Authors and Affiliations
YA Masani , N Mathew, M Chakraborty , JV Kamath
Keywords
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