COMPARATIVE IN VITRO RELEASE STUDY OF SOME COMMERCIALLY AVAILABLE FLUCONAZOLE TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 6
Abstract
Sundry brands of same dosage forms are available in the Indian market with the common assertion that they are all bioequivalent. The main objective of the present study was to conduct the comparative dissolution studies of different brands of same dosage forms to determine whether all the formulations used were bioequivalent or significantly different. AnImmediate release tablets dosage form disintegrate rapidly after administration with enhanced rate of dissolution.Three different brands of Fluconazole (Antifungal) of 150 mg Immediate release tablets from different manufacturers were selected in the study and dissolution testing in 6.8 pH Phosphate buffer was conducted from each brands for 30 minutes by using dissolution testingapparatus USP type-II. The result show that all brand fulfill the specification of dissolution profile and Fumycin’ manufactured by Pfizer was comparatively betterdissolution than other Fluconazole tablets used in experiments.
Authors and Affiliations
Anand Kakde , Nileema Modhave , Arati Patil
Keywords
Related Articles
- EP ID EP118138
- DOI 10.7897/2230-8407.07665
- Views 136
- Downloads 0
A REVIEW ON THE THERAPEUTIC POTENTIALS OF PARTHENOLIDE: A SESQUITERPENE LACTONE
Medicinal plants have been widely employed in treating various diseases for centuries and are still a major resource and repository that can be further exploited for a variety of infectious and non-infectious ailments. T...
DIURETIC ACTIVITY OF BUTEA MONOSPERMA FLOWERS EXTRACT
Kidney, as excretory organ of our body serves important function of excretion of waste products, regulation of fluid volume and electrolyte content etc. Damage to kidney can lead to severe life threatening complications....
MENTAL HEALTH CHALLENGES AND POSSIBLE SOLUTIONS WITH SPECIAL REFERENCE TO ANXIETY
Mental disorders are universal and very common. No country can postpone service development until the finalization of national level epidemiological surveys. It should be noted also that such surveys are very costly and...
SYNTHESIS AND BIOLOGICAL STUDIES OF CHERIMOLACYCLOPEPTIDE E AND ITS N- METHYLATED ANALOG
The N-methyl derivative of Cherimolacyclopeptide E cyclo[Phe-(Dimethyl)Tyr-Pro-Gly-Leu-Gly] was synthesized using solution phase peptide synthesis. The synthesized compound was characterized by spectral data and was eval...
THERMODYNAMICS OF BINARY ALLOYS OF PHARMACEUTICAL ACTIVE IMIDAZOLE WITH O- PHENYLENEDIAMINE
The present study describes the investigation of eutectic and non-eutectic alloys of imidazole (IM) with o - Phenylenediamine (OPD). the solid-liquid equilibrium (SLE) data determined by thaw melt method in the form of m...