THERMODYNAMICS OF BINARY ALLOYS OF PHARMACEUTICAL ACTIVE IMIDAZOLE WITH O- PHENYLENEDIAMINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
The present study describes the investigation of eutectic and non-eutectic alloys of imidazole (IM) with o - Phenylenediamine (OPD). the solid-liquid equilibrium (SLE) data determined by thaw melt method in the form of melting temperature with their corresponding composition construct the solid-liquid equilibrium phase diagram which suggests simple eutectic behaviour is followed by the binary system. The activity co-efficient model based on enthalpy of fusion was employed to calculate the excess partial and integral thermodynamic functions such as gE, hE and sE. These values help to predict the nature of molecular interaction, ordering and stability between the components. The spontaneity of mixing of eutectic and non eutectic alloys was discussed by the partial and integral mixing quantities ∆GM, ∆HM and ∆SM. Using Gibbs-Duhem equation the solution of partial molar heat of mixing, activity and activity coefficient of the component in the binary mix have been resolved.
Authors and Affiliations
H. Shekhar , Y. Roy
Keywords
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