PHYTOCHEMICAL AND CYTOTOXIC STUDIES OF POLYPHENOLIC FLAVONOIDS CONTENTS OF URTICA DIOICA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 12
Abstract
The polyphenolic flavonoids found in several medical plants and herbal remedies containing flavonoids, have been used in folk medicine around the world. The weight of laboratory studies, epidemiological investigation and human clinical trials indicate that polyphenolic chemistry have important effects on cancer chemoprevention and chemo –therapy. Urtica dioica (UD) "stinging nettle" has been consumed for centuries as a phyto-medical agent and as a food substance. Although its history associated with alternative remedies was remarkable but the number of its cytotoxic studies are rather scarce. Therefore, more focused phyto and medicinal chemistry studies are required to establish whether such dietary effects of Urtica dioica ’s extract can be exploited to achieve even preliminary cytotoxic effect on Hep -2 cell line. The major compounds detected and isolated from the ethanolic extract of the aerial parts of Urtica dioica were determined as flavonoids by chromatographic, chemical and spectral (UV, IR) methods. In this paper, the down ward viability -concentration curve of the ethanolic extract of the Urtica dioica ‘s methanolic extract, using Hep-2 cell line indicate its positive cytotoxic activity. The promising results will stimulate the full phytochemical and cytotoxic studies of flavonoids for cancer chemoprevention and chemotherapy. We believe that this one cell line study may be contradictory in part, and gives a conclusion that there's still a long way to go until we do a full phytochemical investigation for Urtica dioica 's different polyphenolic compounds; several works addressing this matter are referred to predict a full cytotoxic profile of Urtica dioica.
Authors and Affiliations
Wafaa M. A. Hamed, Nohad Omari
Keywords
Related Articles
- EP ID EP131239
- DOI 10.7897/2230-8407.041219
- Views 74
- Downloads 0
FT-IR STUDY OF THE EFFECT OF ALUMINIUM AND THE INFLUENCE OF DFO AND DFP ON THE BIO-CHEMICAL CHANGES IN THE KIDNEY OF INDIAN CIRRHINUS MRIGALA
Aluminium is naturally occurring, most abundant element in the earth crust and becomes toxic elevated concentrations are introduced into the environment. Kidney is involved in detoxification and high affinity to removal...
CHELATING PROPERTIES OF CARDIOSPERMUM HALICACABUM AGAINST THE TOXIC EFFECT OF CYPERMETHRIN IN THE QUANTIFICATION OF NUCLEIC ACIDS IN THE FRESH WATER FISH CIRRHINUS MRIGALA (HAMILTON)
Among the pesticides the synthetic pyrethroids are commonly used because of their rapid biodegradability and non-persistent nature. The cypermethrin has a strong pescicidal activity in fresh water fish C. mrigala for al...
ANTIDEPRESSANT ACTIVITY OF HYDROALCOHOLIC EXTRACT OF ZINGIBER OFFICINALE
The present study was design to evaluate the effect of Zingiber officinale hydro-alcoholic extract as well as its interaction with conventional anxiolytic and antidepressant drugs using tail suspension test and forced sw...
ROLE OF HEMATOLOGICAL PARAMETERS IN DIAGNOSIS AND PROGNOSIS OF GASTRIC CARCINOMA IN KASHMIR, INDIA
Gastric cancer is the second leading cause of death in the world. More than two-thirds of the patients are diagnosed at an advanced stage. Metastatic gastric cancer has poor prognosis with a median 5 years-survival rate...
SOLUBILITY ENHANCEMENT OF FENOFIBRATE, A BCS CLASS II DRUG, BY SELF EMULSIFYING DRUG DELIVERY SYSTEMS
The present work was aimed at the enhancement of solubility of Fenofibrate a BCS class II drug by Self Emulsifying Drug Delivery systems (SEDDS). The solubility of Fenofibrate in various excipients was determined. The ex...